About: Lapatinib Ditosylate

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Lapatinib Ditosylate
rdfs:subClassOf	Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor nodeID://b686380 nodeID://b686381 nodeID://b686382 nodeID://b686383
Has_Free_Acid_Or_Base_Form	LAPATINIB
Has_Target	Receptor, Epidermal Growth Factor Receptor, erbB-2
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Lapatinib Ditosylate
UMLS_CUI	C1504917
CAS_Registry	388082-78-8
Accepted_Therapeutic_Use_For	HER2 positive metastatic breast cancer
FDA_UNII_Code	G873GX646R
Contributing_Source	FDA
ALT_DEFINITION	A drug used with another anticancer drug to treat breast cancer that is HER2 positive and has advanced or metastasized (spread to other parts of the body) after treatment with other drugs. Lapatinib ditosylate is also being studied in the treatment of other types of cancer. It is a type of ErbB-2 and EGFR dual tyrosine kinase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID	269659
PDQ_Closed_Trial_Search_ID	269659
Chemical_Formula	C29H26ClFN4O4S.2C7H8O3S.H2O
Legacy_Concept_Name	Lapatinib_Ditosylate
FULL_SYN	LAPATINIB DITOSYLATEPTFDAG873GX646R TykerbPTNCI-GLOSSCDR0000489115 lapatinib ditosylatePTNCI-GLOSSCDR0000539453 Lapatinib DitosylatePTDCP50669 TykerbBRNCI Lapatinib DitosylatePTNCI
DEFINITION	The ditosylate salt of lapatinib, a synthetic, orally-active quinazoline with potential antineoplastic activity. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types.NCI
code	C66878
sameAs	Lapatinib Ditosylate
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0473529
is Has_Salt_Form of	LAPATINIB
is sameAs of	Lapatinib Ditosylate

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