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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Lapatinib
rdfs:subClassOf
Has_Salt_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Lapatinib
PubMedID_Primary_Reference
  • 12214266
NSC_Code
  • 727989
UMLS_CUI
  • C1506770
CAS_Registry
  • 231277-92-2
In_Clinical_Trial_For
  • Breast Cancer; Colorectal Cancer; Liver or Biliary Tract Carcinoma.
FDA_UNII_Code
  • 0VUA21238F
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used with another anticancer drug to treat breast cancer that is HER2 positive and has advanced or metastasized (spread to other parts of the body) after treatment with other drugs. Lapatinib is also being studied in the treatment of other types of cancer. It is a type of ErbB-2 and EGFR dual tyrosine kinase inhibitor.NCI-GLOSS
Chemical_Formula
  • C29H26ClFN4O4S
Legacy_Concept_Name
  • GW572016
CHEBI_ID
  • CHEBI:49603
FULL_SYN
  • GW2016CNNCI
  • LAPATINIBPTFDA0VUA21238F
  • GW572016PTNCI-GLOSSCDR0000302459
  • GW 2016PTDCP50458
  • GW572016CNNCI
  • GSK572016CNNCI
  • LapatinibPTNCI
  • lapatinibPTNCI-GLOSSCDR0000390335
DEFINITION
  • A synthetic, orally-active quinazoline with potential antineoplastic properties. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types.NCI
code
  • C26653
sameAs
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