About: Canertinib Dihydrochloride

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Canertinib Dihydrochloride
rdfs:subClassOf	Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
Has_Free_Acid_Or_Base_Form	Canertinib
Has_Target	Receptor, Epidermal Growth Factor Receptor, erbB-2 Receptor, ErbB-4 Receptor, erbB-3
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Canertinib Dihydrochloride
UMLS_CUI	C0964184
CAS_Registry	289499-45-2
FDA_UNII_Code	ICJ93X8X90
Contributing_Source	FDA
ALT_DEFINITION	A substance being studied in the treatment of some types of cancer. Canertinib blocks the action of proteins called epidermal growth factor receptors, and may cause cancer cells to die. It is a type of tyrosine kinase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID	38403
PDQ_Closed_Trial_Search_ID	38403
Chemical_Formula	C24H25ClFN5O3.2HCl
Legacy_Concept_Name	CI-1033
FULL_SYN	canertinibPTNCI-GLOSSCDR0000560928 PD-0183805-002BCNNCI Canertinib DihydrochloridePTNCI canertinib dihydrochloridePTNCI-GLOSSCDR0000579644 CI-1033PTNCI-GLOSSCDR0000045040 N-[-4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide DihydrochlorideSNNCI CI-1033CNNCI PD183805CNNCI CANERTINIB DIHYDROCHLORIDEPTFDAICJ93X8X90 N-[-4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide DihydrochloridePTDCP50460
DEFINITION	The hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. Canertinib binds to the intracellular domains of epidermal growth factor receptor tyrosine kinases (ErbB family), irreversibly inhibiting their signal transduction functions and resulting in tumor cell apoptosis and suppression of tumor cell proliferation. This agent also acts as a radiosensitizing agent and displays synergistic activity with other chemotherapeutic agents.NCI
code	C1880
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0379097
is Has_Salt_Form of	Canertinib

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