About: Indium In 111 Anti-EGFR Monoclonal Antibody ABT-806

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Attributes	Values
rdf:type	Class
rdfs:label	Indium In 111 Anti-EGFR Monoclonal Antibody ABT-806
rdfs:subClassOf	Radioimmunoconjugate
Has_Target	Receptor, Epidermal Growth Factor
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Indium In 111 Anti-EGFR Monoclonal Antibody ABT-806
NCI_META_CUI	CL433018
PDQ_Open_Trial_Search_ID	717760
PDQ_Closed_Trial_Search_ID	717760
FULL_SYN	111-Indium-ABT806ABNCI Indium In 111 Anti-EGFR Monoclonal Antibody ABT-806PTNCI Indium In 111 ABT-806SYNCI
DEFINITION	A radioimmunoconjugate composed of a humanized monoclonal antibody IgG1 directed against the epidermal growth factor receptor (EGFR) and labeled with the radioisotope indium In 111, with potential radioimaging activity. Indium In 111 anti-EGFR monoclonal antibody ABT-806 binds to a specific epitope of either wild-type or EGFR variant III mutant on tumor cells, thereby allowing imaging of EGFR-expressing tumor cells using gamma scintigraphy. ABT-806 is the humanized version derived from the predecessor chimeric monoclonal antibody 806. EGFR, a receptor tyrosine kinase overexpressed on the cell surfaces of many tumor cell types, plays a key role in tumor cell proliferation.NCI
code	C99169

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