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| Description
| - The cells in multicellular organisms are spatially organized through cell-cell and cell-extracellular matrix interactions. Disruption of adhesive bonds results in enhanced cell motility and helps cells to become invasive - to degrade the basal membrane,escape from their home tissues, invade surrounding tissues and eventually to colonize them. Cell invasiveness plays an important role in the normal embryonic development and also in metastasis - the most dangerous stage of tumours, which is the actual cause of death in approximately 90% of cancer patients. In both cases the cell invasiveness appears to be regulated by similar mechanisms, which are presently known only partially. In order to contribute to the knowledge of cell invasiveness regulation wewill study in parallel selected molecules and molecular mechanisms that regulate cell migration and invasiveness in early vertebrate embryos and in cells of non-invasive and metastasizing experimental tumors. Validation of obtained results will be done i (en)
- Buňky mnohobuněčných organizmů jsou poutány vazbami jedna k druhé nebo k extracelulární matrix, která vyplňuje mezibuněčné prostory. Uvolnění těchto vazeb má za následek zvýšenou pohyblivost buňky a případně i invazivitu - schopnost opustit původní strukturu tkáně, proniknout přirozenými bariérami a případně kolonizovat nové prostory. Buněčná invazivita se významně podílí na normálním vývoji embrya, ale také na nejnebezpečnějším stadiu zhoubného nádoru - metastáze. V obou zmíněných případech je invazivita zřejmě regulována stejnými mechanizmy, jejichž znalost je však zatím pouze částečná. Studiem vybraných molekul a molekulárních mechanizmů regulujících buněčnou invazivitu v časném embryu obratlovce a v buňkách experimentálních nádorů budou určeny ty molekuly, které se na invazivitě buněk významně podílejí. Získané poznatky budou ověřeny na experimentálních nádorech in vivo. Rovněž budou analyzovány lidské nádory, primární i metastázy, se snahou určit, které ze zjištěných molekul se mohou podílet na v
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| Title
| - Center of Cell Invasiveness in Embryonic Development and Tumour Metastases (en)
- Centrum buněčné invazivity v embryonálním vývoji a metastázách nádorů
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - buněčná adheze, buněčná migrace, buněčná invazivita, epitelo-mesenchymový přechod, primární nádory, metastázy, embryonální vývoj, transkripční profilování DNA mikročipy, gen src, gen myb (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - Centrum buněčné invazivity spojilo výzkumné úsilí molekulárních biologů, lékařů a organických chemiků z ÚMG a ÚOCHB AV ČR a Karlovy Univerzity. Invazivita nádorových buněk byla pochopena do té míry, že byla cíleným zásahem do její regulace vyvolána schopnost metastázy. Byly též hlouběji poznány různé typy buněčného pohybu a jejich regulace a připraven originální soubor syntetických látek. (cs)
- The Center of Cell Invasion brought together biologists, physicians and chemists from IMG, IOCB ASCR and Charles University. Understanding the molecular mechanisms of metastasis enabled manipulation with metastatic phenotype of experimental tumor cells. Different modes of cell invasion were characterized and regulatory molecules recognized. A set of original synthetic compounds was prepared. (en)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - buněčná invazivita
- buněčná migrace
- embryonální vývoj
- epitelo-mesenchymový přechod
- gen src
- metastázy
- primární nádory
- transkripční profilování DNA mikročipy
- buněčná adheze
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| is http://linked.open...vavai/riv/projekt
of | - Abnormal myocardial and coronary vasculature development in experimental hypoxia
- Chiral phosphonate internucleotide linkage: A promising modification for chimeric oligonucleotides?
- Prolinol-based nucleoside phosphonic acids: Synthesis and properties
- Synthesis of nucleoside 5'-S-methylphosphonates and related compounds
- From ribonucleoside 5'-aldehydes to ribonucleoside 5'-C-phosphpnates as building blocks for oligonucleotide synthesis
- Nucleoside phosphonic acids in thymidine phosphorylase inhibition: Structure - activity relationship
- On the stereochemistry of C3'-O-P-CH2-O-C4'' phosphonate internucleotide bond, a phosphate isostere
- Prolinol-based nucleoside phosphonic acids: new isosteric conformationally flexible nucleotide analogues
- Pyrrolidine N-alkylphosphonates and related nucleotide analogues: synthesis and stereochemistry
- Conformational evaluation of labeled C3'-O-P-13CH2-O-C4'' phosphonate internucleotide linkage, a phosphodiester isostere
- Synthesis and hybridization of oligonucleotides modified at AMP sites with adenine pyrrolidine phosphonate nucleotides
- A convenient, high-yield synthesis of 1-substituted uracil and thymine derivatives
- Methyl 4-toluenesulfonyloxymethylphosphonate, a new and versatile reagent for the convenient synthesis of phosphonate-containing compounds
- Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase
- Oligomerization of adenosin-5´-O-ylmethylphosphonate, an isopolar AMP analogue: Evaluation of the route to short oligoadenylates
- Involvement of phosphatidylserine externalization in the down-regulation of c-myb expression in differentiating C2C12 cells
- Impact of chicken thrombopoietin and its receptor c-Mpl on hematopoietic cell development
- Industasis, a promotion of tumor formation by nontumorigenic stray cells
- Confocal microscopy reveals Myzitiras and Vthela morphotypes as new signatures of malignancy progression
- The transcription factor EGR1 regulates metastatic potential of v-src transformed sarcoma cells
- The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
- Neoplastic progression of the human breast cancer cell line G3S1 is associated with elevation of cytoskeletal dynamics and upregulation of MT1-MMP
- Fibronectin-Replating Experiment: Procedure and Analysis
- The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells
- The structure of invadopodia in a complex 3D environment
- Stress-induced expression of p53 target genes is insensitive to SNW1/SKIP downregulation
- Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness
- Activation of human RNase L by 2'- and 5'-O-methylphosphonate-modified olygoadenylates
- DNA released by leukemic cells contributes to the disruption of the bone marrow microenvironment
- Downregulation of HOPX controls metastatic behavior in sarcoma cells and identifies genes associated with metastasis
- Utváření cévního řečiště: přehled molekulárních mechanismů a možnosti terapeutického ovlivnění
- Isolation and Characterization of Neural Crest Stem Cells from Adult Human Hair Follicles
- Hox geny a vývoj končetin v klinické medicíně i v experimentu
- Contractile forces in tumor cell migration
- MYZITIRAS AND VTHELA MORPHOTYPES AS NEW SIGNATURES OF NEOPLASTIC PROGRESSION?
- The role of tyrosine 90 in regulation of Src kinase activity and its interaction with signaling partners
- Tetrofuranose nucleoside phosphonic acids: Synthesis and properties
- Synthesis of novel deoxynucleoside S-methylphosphonic acids using S-(diisopropylphosphonomethyl)isothiouronium tosylate, a new equivalent of mercaptomethylphosphonate
- Synthesis of oligoribonucleotides with phosphonate-modified linkages
- Synthesis and properties of ApA analogues with shortened phosphonate internucleotide linkage
- 4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics
- Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling
- Electrophile-promoted addition of hydroxymethylphosphonate to 4',5'-didehydronucleosides: a way to novel isosteric analogues of 5'-nucleotides
- Ring Enlargement of Cyclic Acetals and Ketals: A Way to Seven-Membered Nucleoside Phostones
- The Melanocyte Fate in Neural Crest is Triggered by Myb Proteins through Activation of c-kit
- ROCK inhibitors as emerging therapeutic candidates for sarcomas
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| is http://linked.open...vavai/cep/projekt
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