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Description
  • Analogy nukleosid-fosfonátů a příslušné oligonukleotidy se seskupením P-C-O-C5' mají zaujímavé biochemické a biofyzikálí vlastnosti. Byla připravená série nukleosid-S-metylfosfonátů s vazbou P-C-S-C5'. Tyto sloučeniny slouží jako monoméry pro přípravu modifikovaných oligonukleotidů, přičem náhrada kyslíku v poloze 5' za nukleofilnější, objemnější a lipofilnější síru může ovlivnit jejich biologické a fyzikálněchemické vlastnosti. (cs)
  • Phosphonate analogs of mono- and oligonucleotides with the P-C-O-C5' moiety have interesting biochemical and biophysical properties. A series of novel compounds, S-methylphosphonate-based nucleotides, with the P-C-S-C5' linkage was prepared as monomers for solid phase synthesis of modified oligonucleotides. Replacement of the 5'-oxygen atom with more nucleophilic, bulky, and lipophilic sulfur atom may influence the physicochemical and biological properties of nucleoside 5'-S-methylphosphonates and chimeric oligonucleotides as well.
  • Phosphonate analogs of mono- and oligonucleotides with the P-C-O-C5' moiety have interesting biochemical and biophysical properties. A series of novel compounds, S-methylphosphonate-based nucleotides, with the P-C-S-C5' linkage was prepared as monomers for solid phase synthesis of modified oligonucleotides. Replacement of the 5'-oxygen atom with more nucleophilic, bulky, and lipophilic sulfur atom may influence the physicochemical and biological properties of nucleoside 5'-S-methylphosphonates and chimeric oligonucleotides as well. (en)
Title
  • Synthesis of nucleoside 5'-S-methylphosphonates and related compounds
  • Synthesis of nucleoside 5'-S-methylphosphonates and related compounds (en)
  • Syntéza nukleosid 5'-S-metylfosfonátů a souvisejících sloučenin (cs)
skos:prefLabel
  • Synthesis of nucleoside 5'-S-methylphosphonates and related compounds
  • Synthesis of nucleoside 5'-S-methylphosphonates and related compounds (en)
  • Syntéza nukleosid 5'-S-metylfosfonátů a souvisejících sloučenin (cs)
skos:notation
  • RIV/61388963:_____/08:00312432!RIV09-AV0-61388963
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(LC06061), P(LC06077), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 52
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 398791
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/08:00312432
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • nucleotide; S'-methylphosphonate analog (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [9708BED1E07A]
http://linked.open...i/riv/nazevZdroje
  • Nucleic Acids Symposium Series
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • -
http://linked.open...iv/tvurceVysledku
  • Rosenberg, Ivan
  • Kóšiová, Ivana
http://linked.open...n/vavai/riv/zamer
issn
  • 0261-3166
number of pages
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