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rdf:type
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Description
| - Analogy nukleosid-fosfonátů a příslušné oligonukleotidy se seskupením P-C-O-C5' mají zaujímavé biochemické a biofyzikálí vlastnosti. Byla připravená série nukleosid-S-metylfosfonátů s vazbou P-C-S-C5'. Tyto sloučeniny slouží jako monoméry pro přípravu modifikovaných oligonukleotidů, přičem náhrada kyslíku v poloze 5' za nukleofilnější, objemnější a lipofilnější síru může ovlivnit jejich biologické a fyzikálněchemické vlastnosti. (cs)
- Phosphonate analogs of mono- and oligonucleotides with the P-C-O-C5' moiety have interesting biochemical and biophysical properties. A series of novel compounds, S-methylphosphonate-based nucleotides, with the P-C-S-C5' linkage was prepared as monomers for solid phase synthesis of modified oligonucleotides. Replacement of the 5'-oxygen atom with more nucleophilic, bulky, and lipophilic sulfur atom may influence the physicochemical and biological properties of nucleoside 5'-S-methylphosphonates and chimeric oligonucleotides as well.
- Phosphonate analogs of mono- and oligonucleotides with the P-C-O-C5' moiety have interesting biochemical and biophysical properties. A series of novel compounds, S-methylphosphonate-based nucleotides, with the P-C-S-C5' linkage was prepared as monomers for solid phase synthesis of modified oligonucleotides. Replacement of the 5'-oxygen atom with more nucleophilic, bulky, and lipophilic sulfur atom may influence the physicochemical and biological properties of nucleoside 5'-S-methylphosphonates and chimeric oligonucleotides as well. (en)
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Title
| - Synthesis of nucleoside 5'-S-methylphosphonates and related compounds
- Synthesis of nucleoside 5'-S-methylphosphonates and related compounds (en)
- Syntéza nukleosid 5'-S-metylfosfonátů a souvisejících sloučenin (cs)
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skos:prefLabel
| - Synthesis of nucleoside 5'-S-methylphosphonates and related compounds
- Synthesis of nucleoside 5'-S-methylphosphonates and related compounds (en)
- Syntéza nukleosid 5'-S-metylfosfonátů a souvisejících sloučenin (cs)
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skos:notation
| - RIV/61388963:_____/08:00312432!RIV09-AV0-61388963
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(LC06061), P(LC06077), Z(AV0Z40550506)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388963:_____/08:00312432
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - nucleotide; S'-methylphosphonate analog (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Nucleic Acids Symposium Series
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Rosenberg, Ivan
- Kóšiová, Ivana
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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is http://linked.open...avai/riv/vysledek
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