About: Prolinol-based nucleoside phosphonic acids: Synthesis and properties

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Komerčně dostupný trans- 4- hydroxy- L- prolin byl použit jako výchozí látka pro syntézu nukleotidových analog na bázi prolinolu, obsahujících N-fosfonomethylovou skupinu vázanou na dusíkový atom pyrrolidinového kruhu. Připravené sloučeniny byly testovány na cytotoxickou a protivirovou aktivitu a jejich konformace v roztoku byla zkoumána pomocí NMR. (cs) Commercially available trans- 4- hydroxy- L- proline has been used as a starting material for the synthesis of prolinol-based nucleotide analogues with N-phosphonomethyl moiety attached to the nitrogen atom of pyrrolidine ring. The compounds were tested fot cytotoxic and antiviral properties and subjected to the NMR-based conformational study. Commercially available trans- 4- hydroxy- L- proline has been used as a starting material for the synthesis of prolinol-based nucleotide analogues with N-phosphonomethyl moiety attached to the nitrogen atom of pyrrolidine ring. The compounds were tested fot cytotoxic and antiviral properties and subjected to the NMR-based conformational study. (en)
Title	Prolinol-based nucleoside phosphonic acids: Synthesis and properties Prolinol-based nucleoside phosphonic acids: Synthesis and properties (en) Nukleosidfosfonové kyseliny na bázi prolinu: syntéza a vlastnosti (cs)
skos:prefLabel	Prolinol-based nucleoside phosphonic acids: Synthesis and properties Prolinol-based nucleoside phosphonic acids: Synthesis and properties (en) Nukleosidfosfonové kyseliny na bázi prolinu: syntéza a vlastnosti (cs)
skos:notation	RIV/61388963:_____/08:00312402!RIV09-AV0-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC06061), P(LC06077), P(LC512), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	52
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Rosenberg, Ivan Buděšínský, Miloš Hurychová, Vladimíra Liboska, Radek Vaněk, Václav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	390411
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/08:00312402
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	oligonucleotide phosphonate; nucleoside analogue; pyrrolidine; prolinol (en)
http://linked.open.../riv/klicoveSlovo	nucleoside analogue prolinol pyrrolidine oligonucleotide phosphonate
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[019D50E91AD5]
http://linked.open...i/riv/nazevZdroje	Nucleic Acids Symposium Series
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Cell Invasiveness in Embryonic Development and Tumour Metastases Center for biomolecules and complex molecular systems Center of Chemical Genetics
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	-
http://linked.open...iv/tvurceVysledku	Buděšínský, Miloš Rosenberg, Ivan Vaněk, Václav Liboska, Radek Hurychová, Vladimíra
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0261-3166
number of pages	2 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Prolinol-based nucleoside phosphonic acids: Synthesis and properties Prolinol-based nucleoside phosphonic acids: Synthesis and properties Prolinol-based nucleoside phosphonic acids: Synthesis and properties Prolinol-based nucleoside phosphonic acids: Synthesis and properties

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