About: The role of the tissue microenvironment in the regulation of cancer cell motility and invasion

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	During malignant neoplastic progression the cells undergo genetic and epigenetic cancer-specific alterations that finally lead to a loss of tissue homeostasis and restructuring of the microenvironment. The invasion of cancer cells through connective tissue is a crucial prerequisite for metastasis formation. Although cell invasion is foremost a mechanical process, cancer research has focused largely on gene regulation and signaling that underlie uncontrolled cell growth. More recently, the genes and signals involved in the invasion and transendothelial migration of cancer cells, such as the role of adhesion molecules and matrix degrading enzymes, have become the focus of research. In this review we discuss how the structural and biomechanical properties of extracellular matrix and surrounding cells such as endothelial cells influence cancer cell motility and invasion. During malignant neoplastic progression the cells undergo genetic and epigenetic cancer-specific alterations that finally lead to a loss of tissue homeostasis and restructuring of the microenvironment. The invasion of cancer cells through connective tissue is a crucial prerequisite for metastasis formation. Although cell invasion is foremost a mechanical process, cancer research has focused largely on gene regulation and signaling that underlie uncontrolled cell growth. More recently, the genes and signals involved in the invasion and transendothelial migration of cancer cells, such as the role of adhesion molecules and matrix degrading enzymes, have become the focus of research. In this review we discuss how the structural and biomechanical properties of extracellular matrix and surrounding cells such as endothelial cells influence cancer cell motility and invasion. (en)
Title	The role of the tissue microenvironment in the regulation of cancer cell motility and invasion The role of the tissue microenvironment in the regulation of cancer cell motility and invasion (en)
skos:prefLabel	The role of the tissue microenvironment in the regulation of cancer cell motility and invasion The role of the tissue microenvironment in the regulation of cancer cell motility and invasion (en)
skos:notation	RIV/68378050:_____/10:00355121!RIV11-MSM-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA202/08/0590), P(LC06061), Z(AV0Z50520514), Z(MSM0021620858)
http://linked.open...iv/cisloPeriodika	22
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Veselý, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	285770
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/10:00355121
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	endothelial barrier function; pericellular proteolysis; melanoma cells (en)
http://linked.open.../riv/klicoveSlovo	endothelial barrier function melanoma cells pericellular proteolysis
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B28785CD15AD]
http://linked.open...i/riv/nazevZdroje	Cell communication and signaling : CCS
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Validation of digital holographic microscope in investigations of living cell dynamics & completion of new multifunctional instrument Center of Cell Invasiveness in Embryonic Development and Tumour Metastases
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Veselý, Pavel Brabek, J. Rosel, D. Mierke, C. T. Fabry, B.
http://linked.open...ain/vavai/riv/wos	000282265700003
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Signaling and cellular response mechanisms
issn	1478-811X
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	The role of the tissue microenvironment in the regulation of cancer cell motility and invasion The role of the tissue microenvironment in the regulation of cancer cell motility and invasion The role of the tissue microenvironment in the regulation of cancer cell motility and invasion

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