| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - Protoonkogen c-myb i z něho odvozený onkogen v-mybAMV kódují transkripční regulátory schopné ovlivnit komitment krevních progenitorových buněk. Na rozdíl od proteinu c-Myb, který působí při tvorbě a diferenciaci různých typů progenitorů, onkoprotein v-Myb komituje myeloidní progenitor do linie monocytu a způsobuje jeho transformaci ve stadiu monoblastu. V tomto článku poprvé dokazujeme, že bílkoviny Myb určují buněčný osud i v buňkách neurální lišty, které směrují do linie melanocytu. V buňkách neurální lišty bílkoviny Myb aktivují expresi receptoru c-kit, čímž zřejmě aktivují signál tohoto receptoru. Jak bylo dříve ukázáno, je exprese c-kit v erythroidních progenitorech rovněž závislá na c-Myb. Zdá se tedy, že signální dráha c-myb - c-kit představuje regulační signál společný pro vývoj krevních i neurálních progenitorů. V této práci zároveň představujeme nový experimentální model pro studium melanocytogeneze a transformaci melanocytů. (cs)
- The c-myb proto-oncogene and its oncogenic derivative v-mybAMV encode transcriptional regulators engaged in the commitment of hematopoietic cells. While the c-Myb protein is important for the formation and differentiation of various progenitors, the v-MybAMV oncoprotein induces in chicks a progression and transformation of the single (monoblastic) cell lineage. In this article the evidence is presented that c-Myb and v-MybAMV proteins have cell fate-directing abilities also in avian neural crest (NC), where both proteins determine the melanocytogenesis. Both Myb proteins activate in NC cells expression of the c-kit gene and the stem cell factor-c-Kit signaling – one of the essential pathways in melanocyte development. These observations bring evidence that the c-myb-c-kit pathway represents a common regulatory scheme for both hematopoietic and neural progenitors and establish a novel experimental model for studies of melanocytogenesis and melanocyte transformation.
- The c-myb proto-oncogene and its oncogenic derivative v-mybAMV encode transcriptional regulators engaged in the commitment of hematopoietic cells. While the c-Myb protein is important for the formation and differentiation of various progenitors, the v-MybAMV oncoprotein induces in chicks a progression and transformation of the single (monoblastic) cell lineage. In this article the evidence is presented that c-Myb and v-MybAMV proteins have cell fate-directing abilities also in avian neural crest (NC), where both proteins determine the melanocytogenesis. Both Myb proteins activate in NC cells expression of the c-kit gene and the stem cell factor-c-Kit signaling – one of the essential pathways in melanocyte development. These observations bring evidence that the c-myb-c-kit pathway represents a common regulatory scheme for both hematopoietic and neural progenitors and establish a novel experimental model for studies of melanocytogenesis and melanocyte transformation. (en)
|
| Title
| - The Melanocyte Fate in Neural Crest is Triggered by Myb Proteins through Activation of c-kit
- The Melanocyte Fate in Neural Crest is Triggered by Myb Proteins through Activation of c-kit (en)
- Proteiny Myb indukují v buňkách neurální lišty melanocytární osud cestou aktivace receptoru c-kit (cs)
|
| skos:prefLabel
| - The Melanocyte Fate in Neural Crest is Triggered by Myb Proteins through Activation of c-kit
- The Melanocyte Fate in Neural Crest is Triggered by Myb Proteins through Activation of c-kit (en)
- Proteiny Myb indukují v buňkách neurální lišty melanocytární osud cestou aktivace receptoru c-kit (cs)
|
| skos:notation
| - RIV/68378050:_____/07:00093160!RIV08-AV0-68378050
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA204/06/1728), P(LC06061), Z(AV0Z50520514)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/07:00093160
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - c-myb proto-oncogene; v-mybAMV oncogene; neural crest; cell fate determination; melanocytes; c-kit signal (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - CH - Švýcarská konfederace
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Cellular and Molecular Life Sciences
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Dvořák, Michal
- Karafiát, Vít
- Čermák, Vladimír
- Pajer, Petr
- Dvořáková, Marta
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
| is http://linked.open...avai/riv/vysledek
of | |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)