About: Biocompatible nanofiber scaffolds forming novel drug matrices for the application of biologically and pharmacologically active substances

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About: Biocompatible nanofiber scaffolds forming novel drug matrices for the application of biologically and pharmacologically active substances Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=KAN200520804
Description	The aim of the proposed project is research in the field of polymeric nanofibers and their use for the construction of novel drug carriers suitable for the application of biologically and pharmacologically active substances. Both the absorption and adsorption of biologically active substances to nanofiber scaffolds and the utilization of nanofiber bilayers to encapsulate drug-producing cells will be explored. The biocompatibility and biological properties of these new drug carriers will be tested and characterized in vitro in tissue culture and in experimental animal models. The ultimate goal of this research is the design and production of novel drug carriers based on nanofiber technology that can be widely used for the treatment of serious illnesses. (en) Navrhovaný projekt se zabývá výzkumem v oblasti využití polymerních nanovlákenných nosičů k vytváření nových lékových forem sloužících k cíleným a řízeným aplikacím farmakologicky a biologicky aktivních látek, zejména pak v oblasti imunofarmakologie. Zkoumány budou jak techniky adsorpce a absorpce biologicky aktivních látek na nanovlákenné nosiče, tak i možnost využití nanovlákenných dvojvrstev k enkapsulaci buněčných kultur uvolňujících imunologicky aktivní látky. Biokompatibilita a funkčnost těchto konstruktů budou ověřovány in vitro v tkáňových kulturách a testovány v experimentálních zvířecích modelech. Konečným cílem je navržení a výroba zcela nových lékových forem založených na nanovlákenných technologiích a široce využitelných k léčebným účelům v různých oblastech medicíny.
Title	Biocompatible nanofiber scaffolds forming novel drug matrices for the application of biologically and pharmacologically active substances (en) Biokompatibilní nanovlákenné konstrukty vytvářející nové lékové formy pro aplikaci biologicky a farmakologicky aktivních látek
skos:notation	KAN200520804
http://linked.open...avai/cep/aktivita	Nanotechnologies for Society
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/KAN200520804/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/KAN200520804/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2013-03-26 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	92965852
http://linked.open...ai/cep/hlavniObor	EI - Biotechnologie a bionika
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	nanofibers; nanofiber scaffolds; tissue engineering; biodegradable polymers; hydrogels; pharmacokinetics; immunosuppressives; cytokines; stem cells; immunomodulation; transplantation; therapy of surface lesions (en)
http://linked.open...ep/partnetrHlavni	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...inujicichPrijemcu	1 (xsd:int)
http://linked.open...cep/pocetPrijemcu	4 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	26 (xsd:int)
http://linked.open...enychVysledkuVRIV	26 (xsd:int)
http://linked.open...lneniVMinulemRoce	2012-02-29 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/KAN200520804
http://linked.open...iciPoslednihoRoku	2012
http://linked.open...atUdajeProjZameru	2013
http://linked.open.../vavai/cep/soutez	SAV02008-N
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2012-12-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	CD - Makromolekulární chemie FR - Farmakologie a lékárnická chemie
http://linked.open...ep/zahajeniReseni	2008-01-01 (xsd:date)
http://linked.open...jektu+dodavatelem	Novel constructs of nanofiber scaffolds containing stem cells or pharmacologically active drugs were prepared and characterized. The therapeutic potential of these constructs was proved in experimental models of surface injuries and defects. (en) Byly připraveny a charakterizovány nové formy konstruktů nanovlákenných nosičů s kmenovými buňkami nebo nesoucích farmakologicky aktivní látku a na modelech povrchových tkáňových defektů byl prokázán jejich významný terapeutický potenciál. (cs)
http://linked.open...tniCyklusProjektu	ZBBBKU
http://linked.open.../cep/klicoveSlovo	nanofibers biodegradable polymers cytokines hydrogels immunomodulation immunosuppressives nanofiber scaffolds pharmacokinetics stem cells tissue engineering transplantation
is http://linked.open...vavai/riv/projekt of	Hydrogels in biology and medicine Hydrogels contact lenses Hydrogels in biology and medicine Hydrogels in biology and medicine Distinct regulatory roles of transforming growth factor-beta and interleukin-4 in the development and maintenance of natural and induced CD4+ CD25+ Foxp3+ regulatory T cells Immunoregulatory properties of mouse limbal stem cells Cholesterol-modified superporous poly(2-hydroxyethyl methacrylate) scaffolds for tissue engineering Treatment of ocular surface injuries by limbal and mesenchymal stem cells growing on nanofiber scaffolds Graft survival and cytokine production profile after limbal transplantation in the experimental mouse model Monolithic columns based on a poly(styrene-divinylbenzene-methacrylic acid) copolymer for capillary liquid chromatography of small organic molecules Biomaterials combined with cell therapy for treatment of spinal cord injury Cyclosporine A-loaded and stem cell-seeded electrospun nanofibers for cell-based therapy and local immunosuppression A rapid separation of two distinct populations of mouse corneal epithelial cells with limbal stem cell characteristics by centrifugation on percoll gradient The key role of insulin-like growth factor I in limbal stem cell differentiation and the corneal wound-healing process Controlled gentamicin release from multi-layered electrospun nanofibrous structures of various thicknesses IL-12 inhibits the TGF-beta-dependent T cell developmental programs and skews the TGF-beta-induced differentiation into a Th1-like direction Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing Nanotechnologies for treatment of stroke and spinal cord injury Morphological characterization of nanofibers: methods and application in practice Rheological properties of homogeneous and heterogeneous poly(2-hydroxyethyl methacrylate) hydrogels The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population Novel antifouling self-healing poly(carboxybetaine methacrylamide-co-HEMA) nanocomposite hydrogels with superior mechanical properties Non-fouling hydrogels of 2-hydroxyethyl methacrylate and zwitterionic carboxybetaine (meth)acrylamides Hepatocyte growth on polycapronolactone and 2-hydroxyethylmethacrylate nanofiber sheets enhanced by bone marrow-derived mesenchymal stromal cells. The growth and delivery of mesenchymal and limbal stem cells using copolymer polyamide 6/12 nanofiber scaffolds Nanotechnology for treatment of stroke and spinal cord injury
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