About: The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population

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About: The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Bone marrow-derived mesenchymal stem cells (MSCs) can produce significant levels of transforming growth factor-β and interleukin-6. These two cytokines represent the key factors that reciprocally regulate the development of naive T-cells into regulatory T-cell (Treg) population or proinflammatory T helper 17 (Th17) cells. We demonstrated that MSCs and their products effectively regulate expression of transcription factors Foxp3 and RORγt and control the development of Tregs and Th17 cells in a population of alloantigen-activated mouse spleen cells. The immunomodulatory effects of MSCs were more pronounced when these cells were stimulated by addition of anti-inflammatory or proinflammatory cytokines. The results showed that MSCs represent important players that reciprocally regulate the differentiation of naive T-cells into anti-inflammatory Tregs or proinflammatory Th17 cell population and thereby can modulate immunopathological or transplantation reactions. Bone marrow-derived mesenchymal stem cells (MSCs) can produce significant levels of transforming growth factor-β and interleukin-6. These two cytokines represent the key factors that reciprocally regulate the development of naive T-cells into regulatory T-cell (Treg) population or proinflammatory T helper 17 (Th17) cells. We demonstrated that MSCs and their products effectively regulate expression of transcription factors Foxp3 and RORγt and control the development of Tregs and Th17 cells in a population of alloantigen-activated mouse spleen cells. The immunomodulatory effects of MSCs were more pronounced when these cells were stimulated by addition of anti-inflammatory or proinflammatory cytokines. The results showed that MSCs represent important players that reciprocally regulate the differentiation of naive T-cells into anti-inflammatory Tregs or proinflammatory Th17 cell population and thereby can modulate immunopathological or transplantation reactions. (en)
Title	The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population (en)
skos:prefLabel	The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population (en)
skos:notation	RIV/68378050:_____/12:00375938!RIV13-GA0-68378050
http://linked.open...avai/predkladatel	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(1M0506), P(GAP301/11/1568), P(GAP304/11/0653), P(GD310/08/H077), P(KAN200520804), S, Z(AV0Z50520514), Z(MSM0021620858)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Holáň, Vladimír Pokorná, Kateřina Zajícová, Alena Krulová, Magdalena Procházková, Jana Svobodová, Eliška Trošan, Peter
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	166033
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/12:00375938
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mesenchymal stem cells; immunomodulation; T-cell development (en)
http://linked.open.../riv/klicoveSlovo	immunomodulation T-cell development mesenchymal stem cells
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3DA972C888C9]
http://linked.open...i/riv/nazevZdroje	Stem Cells and Development
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Cellular aspects of transplantation tolerance Targeted differentiation and transdifferentiation of limbal and mesenchymal stem cells and their therapeutic applications in preclinical models Biocompatible nanofiber scaffolds forming novel drug matrices for the application of biologically and pharmacologically active substances Center of Molecular and Cellular Immunology Regulation of immunological mechanisms in health and disease:Development of new diagnostic and therapeutic approaches
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Procházková, Jana Holáň, Vladimír Krulová, Magdalena Svobodová, Eliška Trošan, Peter Zajícová, Alena Pokorná, Kateřina
http://linked.open...ain/vavai/riv/wos	000302222700008
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Signaling and cellular response mechanisms
issn	1547-3287
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1089/scd.2011.0157
is http://linked.open...avai/riv/vysledek of	The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population

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