About: Center of Molecular and Cellular Immunology

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=1M0506
Description	Elucidate immune functions of selected signaling molecules(adaptor proteins PAG, NTAL, LIME, nonreceptor protein-tyrosine and lipid phosphatases) and defects of their functions in some diseases. Identify, clone and functionally chracterize potential noveClarify signal transduction from apoptosis-ducing receptors of the cytokine TRAIL and receptor DR6 and identify the natural ligand of DR6. Introduce production of recombinant factors Wnt1 and Wnt3a and use them for elucidation of the Wnt-signaling pathwaCharacterize the role of signaling and immunoregulatory molecules (cytokines, bacterial toxins and other natural and synthetic immunomodulators) in activation of macrophages and dendritic cells, e.g. in xenotransplantation reactions (cornea transplantatiConstruct a series of commercially potentially interesting: (a) hybridoma cell lines producing monoclonal antibodies to important known and newly discovered immunocyte signaling proteins; (b) relevant recombinant proteins (biologically active fragments o (en) Objasnit imunitní funkce některých signalizačních molekul imunocytů (adaptorové proteiny PAG, NTAL, LIME, nereceptorové fosfatasy) a poruchy jejich funkce u některých onemocnění. Identifikovat, klonovat a funkčně charakterizovat potenciální nové signalizObjasnit přenos signálu z apoptosu indukujících receptorů pro cytokin TRAIL a receptoru DR6 a vyhledat ligand pro DR6. Zavést produkci rekombinantních faktorů Wnt1 a Wnt3a a využít jich pro objasnění úlohy Wnt-signalizační dráhy při potlačení apoptosyCharakterizovat roli signálních a imunoregulačních molekul (cytokinů, bakteriálních toxinů a dalších přirozených a syntetických imunomodulátorů) při aktivaci makrofágů a dendritických buněk, například při xenotransplantačních reakcích (transplantace rohZkonstruovat sérii komerčně potenciálně významných: (a) hybridomových linií produkujících monoklonální protilátky proti důležitým známým a nově objeveným signalizačním proteinů imunocytů; (b) relevantních rekombinantních proteinů (biologicky aktivní frag
Title	Center of Molecular and Cellular Immunology (en) Centrum molekulární a buněčné imunologie
skos:notation	1M0506
http://linked.open...avai/cep/aktivita	The research centres (National research program)
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/1M0506/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/1M0506/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2012-07-03 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	91899889
http://linked.open...ai/cep/hlavniObor	EC - Imunologie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	AP - Aplikovaný výzkum
http://linked.open.../cep/klicovaSlova	adaptor proteins, immunoreceptors, immunomodulators, monoclonal antibodies, recombinant proteins (en)
http://linked.open...ep/partnetrHlavni	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	4 (xsd:int)
http://linked.open.../pocetVysledkuRIV	140 (xsd:int)
http://linked.open...enychVysledkuVRIV	140 (xsd:int)
http://linked.open...lneniVMinulemRoce	2011-02-03 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/14%2F2010-31
http://linked.open...iciPoslednihoRoku	2011
http://linked.open...atUdajeProjZameru	2012
http://linked.open.../vavai/cep/soutez	SMSM2005001M1
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2011-12-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	CE - Biochemie EB - Genetika a molekulární biologie
http://linked.open...ep/zahajeniReseni	2005-01-01 (xsd:date)
http://linked.open...jektu+dodavatelem	Projekt dosáhl významných výsledků v oblasti studia funkcí signalizačních molekul buněk imunitního systému a jejich poruch. Výsledky byly publikovány v kvalitních mezinárodních časopisech. Těžiště práce spočívalo v aplikovaném výzkumu směrovaném na přípravu protilátek a rekombinantních proteinů s komerčním potenciálem, které byly předávány realizačním partnerům. Úroveň řešení byla vysoká. (cs) Important results on immune functions of signaling molecules were obtained. The results were adequately published in high quality international journals. The major emphasis was on applied research aiming at producing commercializable laboratory research tools and at their transfer to industrial partners. The overall quality of the project was high. (en)
http://linked.open...tniCyklusProjektu	ZBBBKBKU
http://linked.open.../cep/klicoveSlovo	adaptor proteins immunoreceptors monoclonal antibodies immunomodulators
is http://linked.open...vavai/riv/projekt of	The transmembrane region is responsible for targeting of adaptor protein LAX into %22heavy rafts'' Tubulins as therapeutic targets in cancer: from bench to bedside Transmembrane adaptor proteins in the high-affinity IgE receptor signaling A simplified technique for evaluating human CCR5 genetic polymorphism γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes Kit- and FceRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells Engagement of phospholipid scramblase 1 in activated cells: implication for phosphatidylserine externalization and exocytosis LFA-1-mediated leukocyte adhesion regulated by interaction of CD43 with LFA-1 and CD147 Cellular and humoral immune responses to chimeric EGFP-pseudocapsids derived from the mouse polyomavirus after their intranasal administration The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1 Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane Distinct regulatory roles of transforming growth factor-beta and interleukin-4 in the development and maintenance of natural and induced CD4+ CD25+ Foxp3+ regulatory T cells Signalling activated by the death receptors of the TNRF family Functional analysis of the posttranslational modifications of the death receptor 6 TRAIL receptor upregulation and the implication of KRAS/BRAF mutations in human colon cancer tumours TRAIL-induced apoptosis of HL60 leukemia cells: Two distinct phenotypes of acquired TRAIL resistance that are accompanied with resistance to TNFa but not to idarubicin and cytarabine Vacuolin-1-modulated exocytosis and cell resealing in mast cells Immunoregulatory properties of mouse limbal stem cells Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts LAT--an important raft-associated transmembrane adaptor protein. Delivered on 6 July 2009 at the 34th FEBS Congress in Prague, Czech Republic What precedes the initial tyrosine phosphorylation of the high affinity IgE receptor in antigen-activated mast cell? The transmembrane adaptor protein NTAL signals to mast cell cytoskeleton via the small GTPase Rho The effects of membrane compartmentalization of csk on TCR signaling The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies - Hydroxylated Anthraquinones Produced by Geosmithia species Treatment of ocular surface injuries by limbal and mesenchymal stem cells growing on nanofiber scaffolds Graft survival and cytokine production profile after limbal transplantation in the experimental mouse model Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling Interaction of late apoptotic and necrotic cells with Vitronectin SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling Cross-reactive anti-human monoclonal antibodies as a tool for B-cell identification in dogs and pigs Francisella tularensis strain LVS resides in MHC II-positive autophagic vacuoles in macrophages Production of nitric oxide during graft rejection is regulated by the TH1/Th2 balance, the arginase activity and L-arginine metabolism Corneal stromal cells selectively inhibit the production of certain anti-inflammatory cytokines Third Acivity of Bordetella Adenylate Cyclase (AC) Toxin-Hemolysin Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function Lifting the fog in store-operated Ca2+ entry Non-lineage antigens: section report Hybridomové buňky produkující monoklonální protilátku TU-30 proti gama-tubulinu Expresní plasmidy produkující části lidských rekombinantních proteinů ARAP1 a DR6 Expresní plasmid produkující mutovanou variantu lidského rekombinantního ligandu TRAIL Expresní plasmid produkující rekombinantní protein EGFP (enhanced green fluorescent protein) Příprava fluorescentně značeného rekombinantního annexin V – FITC. Cyclosporine A-loaded and stem cell-seeded electrospun nanofibers for cell-based therapy and local immunosuppression Fc receptor-γ subunits with both polar or non-polar amino acids at position of T22 are capable of restoring surface expression of the high-affinity IgE receptor and degranulation in γ subunit-deficient rat basophilic leukemia cells A rapid separation of two distinct populations of mouse corneal epithelial cells with limbal stem cell characteristics by centrifugation on percoll gradient T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner The Cyanobacterial Cyclic Lipopeptides Puwainaphycins F/G Are Inducing Necrosis via Cell Membrane Permeabilization and Subsequent Unusual Actin Relocalization Delivery of Large Heterologous Polypeptides across the Cytoplasmic Membrane of Antigen-Presenting Cells by the Bordetella RTX Hemolysin Moiety Lacking the Adenylyl Cyclase Domain Acylation of Lysine 860 Allows Tight Binding and Cytotoxicity of Bordetella Adenylate Cyclase on CD1 1b-Expressing Cells A comparative assessment of mandible shape in a consomic strain panel of the house mouse (Mus musculus) - implications for epistasis and evolvability of quantitative traits IL-12 inhibits the TGF-beta-dependent T cell developmental programs and skews the TGF-beta-induced differentiation into a Th1-like direction LST1/A is a myeloid leukocyte-specific transmembrane adaptor protein recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to the plasma membrane Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing Adenylate Cyclase Toxin Subverts Phagocyte Function by RhoA Inhibition and Unproductive Ruffling RTX cytotoxins recognize Beta2 integrin receptors through N-linked oligosaccharides Oligomerization is involved in pore formation by Bordetella adenylate cyclase toxin

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