About: Nanotechnology for treatment of stroke and spinal cord injury

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Stem cells have been shown to selectively target injured brain and spinal cord tissue and improve functional recovery. To allow cell detection, superparamagnetic iron oxide nanoparticles can be used to label transplanted cells. Magnetic resonance imaging is then a suitable method for the in vivo tracking of grafted cells in the host organism. CNS, and particularly spinal cord, injury is accompanied by tissue damage and the formation of physical and biochemical barriers that prevent axons from regenerating. One aspect of nanomedicine is the development of biologically compatible nanofiber scaffolds that mimic the structure of the extracellular matrix and can serve as a permissive bridge for axonal regeneration or as a drug delivery system. The incorporation of biologically active epitopes and/or the utilization of these scaffolds as stem cell carriers may further enhance their therapeutic efficacy. Stem cells have been shown to selectively target injured brain and spinal cord tissue and improve functional recovery. To allow cell detection, superparamagnetic iron oxide nanoparticles can be used to label transplanted cells. Magnetic resonance imaging is then a suitable method for the in vivo tracking of grafted cells in the host organism. CNS, and particularly spinal cord, injury is accompanied by tissue damage and the formation of physical and biochemical barriers that prevent axons from regenerating. One aspect of nanomedicine is the development of biologically compatible nanofiber scaffolds that mimic the structure of the extracellular matrix and can serve as a permissive bridge for axonal regeneration or as a drug delivery system. The incorporation of biologically active epitopes and/or the utilization of these scaffolds as stem cell carriers may further enhance their therapeutic efficacy. (en)
Title	Nanotechnology for treatment of stroke and spinal cord injury Nanotechnology for treatment of stroke and spinal cord injury (en)
skos:prefLabel	Nanotechnology for treatment of stroke and spinal cord injury Nanotechnology for treatment of stroke and spinal cord injury (en)
skos:notation	RIV/00216208:11130/10:6048!RIV11-MZ0-11130___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1A8697), P(IAA500390902), P(KAN200520804), P(KAN201110651), P(LC554), Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Syková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	273650
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/10:6048
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cell therapy; contrast agents; magnetic resonance; nanofibers; scaffold; spinal cord lesion; mesenchymal stem-cells; superparamagnetic iron-oxide; magnetic-resonance tracking; peptide nanofiber scaffold; traumatic brain-injury; central-nervous-system; in-vivo; bone-marrow; rat-brain; electrospun nanofibers (en)
http://linked.open.../riv/klicoveSlovo	magnetic-resonance tracking peptide nanofiber scaffold spinal cord lesion superparamagnetic iron-oxide traumatic brain-injury scaffold central-nervous-system magnetic resonance nanofibers cell therapy in-vivo mesenchymal stem-cells contrast agents electrospun nanofibers bone-marrow rat-brain
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[4268A562D675]
http://linked.open...i/riv/nazevZdroje	Nanomedicine
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	The utilization of biocompatible macroporous hydrogels containing cell cultures in the therapy of spinal cord injuries The use of stem cells and biomaterials for spinal cord injury repair Neuroscience Centre Biocompatible nanofiber scaffolds forming novel drug matrices for the application of biologically and pharmacologically active substances Combined contrast agents for molecular MR imaging
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Syková, Eva Kubinova, S.
http://linked.open...ain/vavai/riv/wos	000273674900015
http://linked.open...n/vavai/riv/zamer	New biotechnologies, nanomaterials and stem cells for use in regenerative medicine
issn	1743-5889
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	11130
is http://linked.open...avai/riv/vysledek of	Nanotechnology for treatment of stroke and spinal cord injury Nanotechnology for treatment of stroke and spinal cord injury Nanotechnology for treatment of stroke and spinal cord injury

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