About: Controlled gentamicin release from multi-layered electrospun nanofibrous structures of various thicknesses

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Polyvinyl alcohol nanofibers incorporating the wide spectrum antibiotic gentamicin were prepared by Nanospider needleless technology. A polyvinyl alcohol layer, serving as a drug reservoir, was covered from both sides by polyurethane layers of various thicknesses. The multilayered structure of the nanofibers was observed using scanning electron microscopy, the porosity was characterized by mercury porosimetry, and nitrogen adsorption/desorption measurements were used to determine specific surface areas. The stability of the gentamicin released from the electrospun layers was proved by high-performance liquid chromatography (HPLC) and inhibition of bacterial growth. Drug release was investigated using in vitro experiments with HPLC/MS quantification, while the antimicrobial efficacy was evaluated on Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa. Both experiments proved that the released gentamicin retained its activity and showed that the retention of the drug in the nanofibers was prolonged with the increasing thickness of the covering layers. Polyvinyl alcohol nanofibers incorporating the wide spectrum antibiotic gentamicin were prepared by Nanospider needleless technology. A polyvinyl alcohol layer, serving as a drug reservoir, was covered from both sides by polyurethane layers of various thicknesses. The multilayered structure of the nanofibers was observed using scanning electron microscopy, the porosity was characterized by mercury porosimetry, and nitrogen adsorption/desorption measurements were used to determine specific surface areas. The stability of the gentamicin released from the electrospun layers was proved by high-performance liquid chromatography (HPLC) and inhibition of bacterial growth. Drug release was investigated using in vitro experiments with HPLC/MS quantification, while the antimicrobial efficacy was evaluated on Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa. Both experiments proved that the released gentamicin retained its activity and showed that the retention of the drug in the nanofibers was prolonged with the increasing thickness of the covering layers. (en)
Title	Controlled gentamicin release from multi-layered electrospun nanofibrous structures of various thicknesses Controlled gentamicin release from multi-layered electrospun nanofibrous structures of various thicknesses (en)
skos:prefLabel	Controlled gentamicin release from multi-layered electrospun nanofibrous structures of various thicknesses Controlled gentamicin release from multi-layered electrospun nanofibrous structures of various thicknesses (en)
skos:notation	RIV/68378041:_____/12:00381636!RIV13-AV0-68378041
http://linked.open...avai/predkladatel	Ústav experimentální medicíny Akademie věd České republiky, v. v. i.
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(KAN200520804), S, Z(AV0Z40500505), Z(AV0Z50390512), Z(AV0Z50520514), Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	8 October
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Syková, Eva Kubinová, Šárka Mareková, Dana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	128725
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/12:00381636
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nanofibers; electrospinning; multilayered structure (en)
http://linked.open.../riv/klicoveSlovo	electrospinning nanofibers multilayered structure
http://linked.open...odStatuVydavatele	NZ - Nový Zéland
http://linked.open...ontrolniKodProRIV	[F109AD2B61C1]
http://linked.open...i/riv/nazevZdroje	International Journal of Nanomedicine
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Biocompatible nanofiber scaffolds forming novel drug matrices for the application of biologically and pharmacologically active substances
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Hobzová, Radka Michálek, Jiří Syková, Eva Širc, Jakub Holáň, Vladimír Kubinová, Šárka Mareková, Dana Bosáková, Z. Kozlík, P. Stránská, D.
http://linked.open...ain/vavai/riv/wos	000309514800001
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	1178-2013
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.2147/IJN.S35781
is http://linked.open...avai/riv/vysledek of	Controlled gentamicin release from multi-layered electrospun nanofibrous structures of various thicknesses

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