About: Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Electrospun gelatin and poly-epsilon-caprolactone (PCL) nanofibers were prepared using needleless technology and their biocompatibility and therapeutic efficacy have been characterized in vitro in cell cultures and in an experimental model of a skin wound. The effect of nanofibers on wound healing was examined using a full thickness wound model in rats and compared with a standard control treatment with gauze. Significantly faster wound closure was found with gelatin after 5 and 10 days of treatment, but no enhancement with PCL nanofibers was observed. Histological analysis revealed enhanced epithelialisation, increased depth of granulation tissue and increased density of myofibroblasts in the wound area with gelatin nanofibers. The results show that gelatin nanofibers produced by needleless technology accelerate wound healing and may be suitable as a scaffold for cell transfer and skin regeneration. Electrospun gelatin and poly-epsilon-caprolactone (PCL) nanofibers were prepared using needleless technology and their biocompatibility and therapeutic efficacy have been characterized in vitro in cell cultures and in an experimental model of a skin wound. The effect of nanofibers on wound healing was examined using a full thickness wound model in rats and compared with a standard control treatment with gauze. Significantly faster wound closure was found with gelatin after 5 and 10 days of treatment, but no enhancement with PCL nanofibers was observed. Histological analysis revealed enhanced epithelialisation, increased depth of granulation tissue and increased density of myofibroblasts in the wound area with gelatin nanofibers. The results show that gelatin nanofibers produced by needleless technology accelerate wound healing and may be suitable as a scaffold for cell transfer and skin regeneration. (en)
Title	Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing (en)
skos:prefLabel	Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing (en)
skos:notation	RIV/68378041:_____/12:00379338!RIV13-AV0-68378041
http://linked.open...avai/predkladatel	Ústav experimentální medicíny Akademie věd České republiky, v. v. i.
http://linked.open...avai/riv/aktivita	I P S V Z
http://linked.open...avai/riv/aktivity	I, P(1M0506), P(1M0538), P(2B06130), P(GA304/07/1129), P(IAA500390902), P(KAN200520804), S, V, Z(AV0Z40500505), Z(AV0Z50390703), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Syková, Eva Kubinová, Šárka Lesný, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	152920
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/12:00379338
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nanofibers; electrospinning; wound healing (en)
http://linked.open.../riv/klicoveSlovo	wound healing electrospinning nanofibers
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D71171D1C98C]
http://linked.open...i/riv/nazevZdroje	Journal of Materials Science-Materials in Medicine
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	The use of stem cells and biomaterials for spinal cord injury repair Center for Cell Therapy and Tissue Repair Polarised cultures of hepatocytes and mesenchymal cells on the nanofiber membranes in the experimental bioreactor Biocompatible nanofiber scaffolds forming novel drug matrices for the application of biologically and pharmacologically active substances Center of Molecular and Cellular Immunology Synthesis of new biomaterials and preparation of stem cell derived cells, and their aplications in for the treatment of diseases affecting human tissues derived from mesoderm: cartilage, bone, ligament and meniscus.
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Michálek, Jiří Syková, Eva Širc, Jakub Holáň, Vladimír Kubinová, Šárka Munzarová, M. Zajícová, Alena Zajíček, R. Dubský, M. Jirkovská, A. Lesný, Petr Voska, L.
http://linked.open...ain/vavai/riv/wos	000302345400008
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie New biotechnologies, nanomaterials and stem cells for use in regenerative medicine Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0957-4530
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s10856-012-4577-7
is http://linked.open...avai/riv/vysledek of	Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing

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