About: Electrodes modified with nucleic acids and proteins.New tools in biochemical and biomedical research.

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Electrodes modified with nucleic acids and proteins.New tools in biochemical and biomedical research. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=GV204/97/K084
Description	This project of complex studies of biomacromolecule interactions with electrically charged surfaces is based on the recent progress reached in the proposers' laboratories (see the text) in the development of the electrochemical techniques and in the studies of interactions of nucleic acids and proteins with the mercury electrode and solid surfaces. In this project basic information about the adsorption/desorption, redox properties and structural features of DNA, RNA, oligonucleotides, proteins and small peptides at interfaces will be obtained. As a result of these studies electrochemical ultramicromethods will be developed including (a) fast response sensors of the DNA damage (b) fast response sensors of the DNA hybridization c new methods for studies of the interaction of DNA with specific proteins and anticancer drugs, etc. In addition information about the DNA local structures in neurological genetic diseases and about the DNA-p53 protein interactions in human cancer will be obtained. The m (en) Tento projekt komplexního výzkumu interakcí biomakromolekul s elektricky nabitými povrchy je založen na nedávném pokroku dosaženém v laboratořích navrhovatelů (viz text) při rozvoji elektrochemických technik a při studiích interakcí nukleových kyselin a bílkovin se rtuťovou elektrodou a pevnými elektrodami. V tomto projektu budou získány základní informace o adsorpci a desorpci, redoxních a strukturních vlastnostech DNA, RNA, oligonukleotidů, bílkovin a malých peptidů na mezifází. Výsledkem těchto studibude vývoj elektrochemických vysoce citlivých metod, zahrnujících (a) rychle reagující senzory poškození DNA, (b) rychle reagující senzory hybridizace DNA, (c) nové metody pro studium interakcí DNA se specifickými bílkovinami a protinádorově účinnými léčivy, apod. Rovněž bude získána informace o lokálních strukturách DNA při neurologických genetických onemocněních a o interakcích DNA s bílkovinou p53 u lidské rakoviny. Hlavním cílem je vývoj elektrod modifikovaných nukleovými kyselinami a bílkovinami
Title	Electrodes modified with nucleic acids and proteins.New tools in biochemical and biomedical research. (en) Elektrody modifikované nukleovými kyselinami a bílkovinami. Nové nástroje v biochemickém a biomedicínském výzkumu
skos:notation	GV204/97/K084
http://linked.open...avai/cep/aktivita	Comprehensive projects
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/GV204%2F97%2FK084/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/GV204%2F97%2FK084/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2002-11-19 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	877064
http://linked.open...ai/cep/hlavniObor	CE - Biochemie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open.../cep/klicovaSlova	Neuvedeno. (en)
http://linked.open...ep/partnetrHlavni	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	3 (xsd:int)
http://linked.open.../pocetVysledkuRIV	166 (xsd:int)
http://linked.open...enychVysledkuVRIV	166 (xsd:int)
http://linked.open...iciPoslednihoRoku	2002
http://linked.open...atUdajeProjZameru	2002
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open.../cep/vedlejsiObor	CF - Fyzikální chemie a teoretická chemie EB - Genetika a molekulární biologie
http://linked.open...jektu+dodavatelem	Projekt přinesl objasnění elektrochemických vlastností peptidové nukleové kyseliny při její aplikaci jako detektoru hybridizace DNA a při detekci bodové mutace genu p53. Výsledky ukazují cestu k rozvoji nového typu biosenzorů hybridizace DNA. Pokrokem je (cs)
http://linked.open...tniCyklusProjektu	ZBBBKU
is http://linked.open...vavai/riv/projekt of	Electrochemical Elimination Methods Electrochemistry of nucleic acids and proteins. Sensors for DNA hybridization and DNA damage. Electrochemical investigation of rabbit liver metallothionein at a mercury electrode Elimination voltammetry of nucleic acids on silver electrodes Elimination Voltammetry of Adenine and Cytosine Mixtures Electrochemical Detection of Interactions of Echinomycin with DNA at Mercury Film Electrodes (MFE). Electrochemical impedance spectroscopy of single-stranded and double-helical polynucleotides Electrochemical detection of the interactions of chinoxaline and antracykline antibiotics with DNA Electrochemical impedance spectroscopy of polynucleotides. Electrocatalysis of Hydrogen Evolution by Transition Metal Complexes. Electrochemistry of nucleic acids and proteins. Sensing of DNA interactions. Elimination voltammetry of nucleic acids on silver electrodes. Electrochemical impedance spectroscopy of polynucleotides. Electrochemistry of nucleic acids and proteins. Sensors for DNA hybridization and DNA damage. Electrochemical impedance spectroscopy of single-stranded and double-helical polynucleotides. Combination of adsorptive transfer stripping voltammetry and elimination voltammetry Copper solid amalgam electrodes Two-dimensional condensation of nucleic acid components at mercury film and gold electrodes. Voltammetric microanalysis of DNA adducts with osmium tetroxide,2,2'-bipyridine using a pyrolytic graphite electrode. Voltammetry of two single-stranded isomeric end-labeled -SH deoxyoligonucleotides on mercury electrodes. Application of Elimination Voltammetry to the Resolution of Adenine and Cytosine Signals in Oligonucleotides. I. Homo-oligodeoxynucleotides dA9 and dC9 Application of elimination voltammetry with linear scan in bioelectrochemistry Elimination voltammetry of oligonucleotides Generalized principle of elimination voltammetry N/A Voltammetry of native double-stranded, denatured and degraded DNAs. Tumor supressor protein p53 binds preferentially to supercoiled DNA. Thioguanine and Thiouracil: Hydrogen-Bonding and Stacking Propeties. Development of Renewed Mercury Multi-purpose (Multi-mode, Versatile) Microelectrodes, a Part of PC-controlled Measuring Systems (Including the PC-ETP). Effect of Surfactants and Related Biological Active Substances on the O 2 /H 2 O 2 Voltammetry and Its Utilization for Determination of the Total Surfactant Content. Constant Current Chronopotentiometric Stripping Analysis of Bioactive Peptides at Mercury and Carbon Electrodes. N/A N/A Voltammetric Methods for Speciation of Plant Metallothioneins. Eliminační polarografie a eliminační voltametrie Elimination Voltammetry - Modern Electroanalytical Method for Resolution of Overlapped Voltammetric Signals Electrochemical Reactivity of Homocysteine at Mercury Electrodes as Compared with Cysteine. Elektrochemické biosenzory pro poškození DNA a látky poškozující DNA. Cleavage of Supercoiled DNA by Deoxyribonuclease I in Solution and at the Electrode Surface. Effect of p53 Protein Redox States on Binding to Supercoiled and Linear DNA. DNA Bending Due to Specific p53 and p53 Core Domain-DNA Interactions Visualized by Electron Microscopy. Real-time monitoring of enzymatic cleavage of nucleic acids using a quartz crystal microbalance. Reduction and oxidation of peptide nucleic acid and DNA at mercury and carbon electrodes. Voltammetric Methods in Isolation and Identification of Plant Metallothioneins from Alga Chlorella. Voltammetric Methods in the Isolation and Identification of Plant Metallothioneins. Voltammetry of Biologically Active Species and Surfactants on New Miniaturized and Contractible (Compressible) Mercury Electrodes. Application of Elimination Voltammetry to Adsorptive Stripping of DNA Application of Elimination Voltammetry to the Electroanalysis of an Adsorbed Substance Application of Elimination Methods in Electrochemical Study of DNA Application of Elimination Methods in Electrochemical Study of DNA Co je biofyzika ? Constant Current Chronopotentiometric Stripping Analysis of Cd-Metallothionein on Carbon and Mercury Electrodes. Comparison with Voltammetry. Modified electrodes in molecular biology and medicine New Aspects of the Brdička Reaction of Low-Molecular Thiols; Voltammetry at Low Rate of Potential Scan. Mercury Film Electrode as a Sensor for the Detection of DNA Damage. Relation between Electrosorption and Adsorptive Stripping Voltammetry/Tensammetry on Mercury and other Electrodes. The 'Presodium' Catalysis of Electroreduction of Hydrogen Ions on Mercury Electrodes by Metallothionein. An Investigation by Constant Current Derivative Stripping Chronopotentiometry. Use of artificial neural networks for the evaluation of electrochemical signals of adenine and cytosine in mixtures Use of artificial neural networks for the evaluation of electrochemical signals of adenine and cytosine in mixtures interfered with hydrogen evolution Two-dimensional condensation of nucleic acid components at mercury film and gold electrodes Application of carbon electrodes modified with a mercury layer of a different thickness for studies of the adsorption and kinetics of phase transients of cytidine. Differential Pulse Voltammetric Study of the Complexation of Cd(II) by the Phytochelatin (.gamma. -Glu-Cys)2Gly Assisted by Multivariate Curve Resolution. Determination of Iodates using Silver Solid Amalgam Electrodes. Cyclic voltammetry of echinomycin and its interaction with double-stranded and single-stranded DNA adsorbed at the electrode. DNA hybridization at microbeads with cathodic stripping voltammetric detection. Determination of glutathione-S-transferase traces in preparations of p53 C-terminal domain (aa320-393). Determination of nanogram quantities of osmium-labeled single stranded DNA by differential pulse stripping voltammetry. On the formation kinetics of two-dimensional cytidine films. Nonmonotonous Interfacial Behavior of Chloranilic Acid and Its Voltammetrically Active Complexes with V and Mo on Mercury Electrode.

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 41 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software