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| Description
| - A special type of self-association of macromolecules is investigated that leads to creation of nanoparticles in a liquid environment (water, organic solvents, liquid mixtures). Nanoparticles are created by a change in an external parameter, usually temperature or pH. Short-range attraction and long-range repulsion are required for controlled self-association. Various physical interactions are used to provide the short-range attraction: hydrogen bonding, thermoresponsive association of polypeptides, selective sorption of incompatible solvents to diblock copolymers. Long-range repulsion is provided by the incompatibility between the blocks and/or incompatibility of blocks with the surrounding liquid. The repulsion depends on external variables. Polymeric nanoparticles can be created permanently or be reversibly disassembled by an inverse change of the external stimulus. They can also be permanently disassembled by degradation. Efforts will be made to control their size, polydispersity and structure as required by applications envisaged in drug delivery, nanocontainers or nanoreactors. (en)
- Podstatou projektu je výzkum speciálního typu asociativního chování makromolekul, které vede k tvorbě nanočástic v kapalném prostředí (voda, organická rozpouštědla, směsi kapalin). Nanočástice vznikají reakcí na změnu externího parametru, obvykle teploty nebo pH. Pro řízenou tvorbu nanočástic systém musí mít přitažlivé interakce na krátkou vzdálenost a odpudivé interakce na dlouhou vzdálenost. Jsou používány různé fyzikální interakce působící přitažlivě na krátkou vzdálenost: vodíkové můstky, termoresponsivní asociace polypeptidů, selektivní sorpce nemísitelných rozpoštědel na blokový kopolymer. Odpudivá interakce je vyvolána nekompatibilitou mezi bloky nebo bloků a okolního prostředí, rovněž závisí na vnějších proměnných (teplota, pH). Nanočástice jsou vytvořeny buď trvale nebo mohou být reverzibilně rozloženy opačnou změnou vnější proměnné. Mohou též být trvale rozloženy degradací. Pozornost bude soustředěna na řízení rozměru, polydisperzity a struktury nanočástic v hodnotách odpovídajících zamýšleným aplikacím v oblasti cíleného transportu léčiv, nanokontejnerů, nanoreaktorů.
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| Title
| - Bioinspired nanoparticles sensitive to environment stimuli (en)
- Bioinspirované nanočástice reagující na změny vnějšího prostředí
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - nanoparticles hydrogen bonds self-association (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - Projekt se zabýval přípravou a vyhodnocením fyzikálně-chemických vlastností funkčních bioinspirovaných polymerních systémů a nanočástic v kapalném prostředí, jejichž vznik a vlastnosti jsou citlivé na stimuly vnějšího prostředí, jako jsou teplota nebo pH. Byly sestrojeny polymerní systémy pro cílený transport léčiv. Vzniklo 27 publikací v mezinárodních impaktovaných časopisech, 2 kapitoly knihy. (cs)
- The project dealt with a preparation and characterisation of the physico-chemical properties of bioinspired polymer systems and nanoparticles in a liquid medium whose formation and properties are sensitive to environmental stimuli (pH, temperature). The polymeric systems for targeted drug delivery were constructed. The result is a 27 international impacted publications and 2 book chapters. (en)
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| http://linked.open...tniCyklusProjektu
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| is http://linked.open...vavai/riv/projekt
of | - Heterogeneity of accelerated photooxidation in commodity polymers stabilized by HAS: ESRI, IR, and MH study
- Thermoresponsive nanoparticles based on poly(2-alkyl-2-oxazolines) and pluronic F127
- Biopolymer-based degradable nanofibres from renewable resources produced by freeze-drying
- Critical behavior of nanoparticle-containing binary liquid mixtures
- Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: a step forward
- Internal structural characterization of triblock copolymer micelles with looped corona chains
- Combination of %22living%22 nitroxide-mediated and photoiniferter-induced %22grafting from%22 free-radical polymerizations: from branched copolymers to unimolecular micelles and microgels
- Dynamics of PMMA-PHSA hard spheres under external electric field at low temperatures: a singular dynamic light scattering experiment
- Hybrid polymeric micelles based on poly(styrene-b-2-vinyl- 1-methylpyridinium iodide-b-ethylene oxide) and tungstate
- Self-assembled structures in d8-polystyreneblock- polyisoprene/polystyrene blends in the weak segregation regime: SAXS and TEM study
- New hydrophilic HPMA-based polymers for bioreversible shielding of gene delivery vectors
- Hydration modes of an amphiphilic molecule: NMR, FTIR and theoretical study of the interactions in the system water-lutidine
- Heat-set poly(ethylacrylic acid) nanoparticles: combined light scattering, calorimetric, and FTIR study
- A new approach to polymer self-assembly into stable nanoparticles: poly(ethylacrylic acid) homopolymers
- Thermoresponsive hydrolytically degradable polymer micelles intended for radionuclide delivery
- Effects of pressure and temperature on the self-assembled fully hydrated nanostructures of monoolein-oil systems
- Synthesis and thermal behavior of telechelic poly(butadiene)diols with azobenzene-based liquid-crystalline units in side chains
- Synthesis of thermally responsive cylindrical molecular brushes via a combination of nitroxide-mediated radical polymerization and “grafting onto strategy
- Effect of hydrophobic interactions on properties and stability of DNA-polyelectrolyte complexes
- New coupling strategy for radionuclide labeling of synthetic polymers
- Stimuli responsive polymeric micelles for drug delivery purposes
- Polyoxazoline thermoresponsive micelles as radionuclide delivery systems
- Chemical conjugation of cowpea mosaic viruses with reactive HPMA-based polymers
- Structure of micelles formed by highly asymmetric polystyrene-b-polydimethylsiloxane and polystyrene-b-poly[5-(N,N-diethylamino)isoprene] diblock copolymers
- SAXS investigation of a cubic to a sponge (L3) phase transition in self-assembled lipid nanocarriers
- Self-assembled multicompartment liquid crystalline lipid carriers for protein, peptide, and nucleic acid drug delivery
- Topology and internal structure of PEGylated lipid nanocarriers for neuronal transfection: synchrotron radiation SAXS and cryo-TEM studies
- Synthesis of densely grafted copolymers with tert-butyl methacrylate/2-(dimethylamino ethyl) methacrylate side chains as precursors for brush polyelectrolytes and polyampholytes
- Self-association of bee propolis: Effects on pharmaceutical applications
- Silicon nanocrystals and nanodiamonds in live cells: photoluminescence characteristics, cytotoxicity and interaction with cell cytoskeleton
- Silver-coated monolithic columns for separation in radiopharmaceutical applications
- Combination chemotherapy using core-shell nanoparticles through the self-assembly of HPMA-based copolymers and degradable polyester
- Glycogen as a biodegradable construction nanomaterial for in vivo use
- Polymeric nanoparticles stabilized by surfactants: controlled phase separation approach
- Self-assembled polymeric chelate nanoparticles as potential theranostic agents
- Stimuli-responsive spherical brushes based on D-galactopyranose and 2-(dimethylamino)ethyl methacrylate
- Effect of cyclodextrins on pH-induced conformational transition of poly(methacrylic acid)
- Novel polymeric nanoparticles assembled by metal ion addition
- Polymeric nanoparticles stabilized by surfactants investigated by light scattering, small-angle neutron scattering, and Cryo-TEM methods
- Preparation of stable Pd nanocubes and their use in biological labeling
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| is http://linked.open...vavai/cep/projekt
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