About: Thermoresponsive nanoparticles based on poly(2-alkyl-2-oxazolines) and pluronic F127

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We synthesized statistical poly(2-isopropyl-2-oxazoline– co –2-butyl-2-oxazolines) (POXs) that are molecularly dissolved below their cloud point temperature in aqueous milieu and are incorporated into micellar nanoparticles of biocompatible Pluronic F127 (F127) after heating their solution above transition temperature, T tr . A functional comonomer 2-(but-3-enyl)-2-oxazoline copolymerized into one of the POXs (polymer E) allows introduction of fenolic moieties and subsequent radionuclide labeling with iodine-125. Self-assembly of the polymer E with F127 leads to formation of radioactive nanoparticles with hydrodynamic diameter 20 nm in aqueous solution by heating to 37° C. The nanoparticles are intended to be used as radioimaging tool in solid tumor diagnostics. We synthesized statistical poly(2-isopropyl-2-oxazoline– co –2-butyl-2-oxazolines) (POXs) that are molecularly dissolved below their cloud point temperature in aqueous milieu and are incorporated into micellar nanoparticles of biocompatible Pluronic F127 (F127) after heating their solution above transition temperature, T tr . A functional comonomer 2-(but-3-enyl)-2-oxazoline copolymerized into one of the POXs (polymer E) allows introduction of fenolic moieties and subsequent radionuclide labeling with iodine-125. Self-assembly of the polymer E with F127 leads to formation of radioactive nanoparticles with hydrodynamic diameter 20 nm in aqueous solution by heating to 37° C. The nanoparticles are intended to be used as radioimaging tool in solid tumor diagnostics. (en)
Title	Thermoresponsive nanoparticles based on poly(2-alkyl-2-oxazolines) and pluronic F127 Thermoresponsive nanoparticles based on poly(2-alkyl-2-oxazolines) and pluronic F127 (en)
skos:prefLabel	Thermoresponsive nanoparticles based on poly(2-alkyl-2-oxazolines) and pluronic F127 Thermoresponsive nanoparticles based on poly(2-alkyl-2-oxazolines) and pluronic F127 (en)
skos:notation	RIV/61389013:_____/12:00381219!RIV13-AV0-61389013
http://linked.open...avai/predkladatel	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GA202/09/2078), P(GPP207/10/P054), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	19
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Štěpánek, Petr Pánek, Jiří Hrubý, Martin Kučka, Jan Filippov, Sergey Bogomolova, Anna Rabyk, Maria
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	174337
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/12:00381219
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nanoparticles; pluronic F127; poly(2-alkyl-2- oxazoline)s (en)
http://linked.open.../riv/klicoveSlovo	pluronic F127 poly(2-alkyl-2- oxazoline)s nanoparticles
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[9B495590ABB6]
http://linked.open...i/riv/nazevZdroje	Macromolecular Rapid Communications
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Polymeric micelles with metal ion – assembled core Bioinspired nanoparticles sensitive to environment stimuli
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	33
http://linked.open...iv/tvurceVysledku	Filippov, Sergey Hrubý, Martin Pánek, Jiří Štěpánek, Petr Kučka, Jan Bogomolova, Anna Rabyk, Maria
http://linked.open...ain/vavai/riv/wos	000309451000009
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	1022-1336
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/marc.201200254
is http://linked.open...avai/riv/vysledek of	Thermoresponsive nanoparticles based on poly(2-alkyl-2-oxazolines) and pluronic F127

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