About: Self-assembled polymeric chelate nanoparticles as potential theranostic agents

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Improvements in cancer diagnostics and therapy have recently attracted the interest of many different branches of science. This study presents one of the new possible approaches in the diagnostics and therapy of cancer by using polymeric chelates as carriers. Graft copolymers with a backbone containing 8-hydroxyquinoline-5-sulfonic acid chelating groups and poly(ethylene oxide) hydrophilic grafts are synthesized and characterized. The polymers assemble and form particles after the addition of a biometal cation, such as iron or copper. The obtained nanoparticles exhibit a hydrodynamic diameter of around 25 nm and a stability of at least several hours, which are counted as essential parameters for biomedical purposes. To prove their biodegradability, a model degradation with deferoxamine is performed and, together with high radiolabeling efficiency with copper-64, their possible use for nuclear medicine purposes is demonstrated. Improvements in cancer diagnostics and therapy have recently attracted the interest of many different branches of science. This study presents one of the new possible approaches in the diagnostics and therapy of cancer by using polymeric chelates as carriers. Graft copolymers with a backbone containing 8-hydroxyquinoline-5-sulfonic acid chelating groups and poly(ethylene oxide) hydrophilic grafts are synthesized and characterized. The polymers assemble and form particles after the addition of a biometal cation, such as iron or copper. The obtained nanoparticles exhibit a hydrodynamic diameter of around 25 nm and a stability of at least several hours, which are counted as essential parameters for biomedical purposes. To prove their biodegradability, a model degradation with deferoxamine is performed and, together with high radiolabeling efficiency with copper-64, their possible use for nuclear medicine purposes is demonstrated. (en)
Title	Self-assembled polymeric chelate nanoparticles as potential theranostic agents Self-assembled polymeric chelate nanoparticles as potential theranostic agents (en)
skos:prefLabel	Self-assembled polymeric chelate nanoparticles as potential theranostic agents Self-assembled polymeric chelate nanoparticles as potential theranostic agents (en)
skos:notation	RIV/61389013:_____/12:00386090!RIV13-AV0-61389013
http://linked.open...avai/predkladatel	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GA202/09/2078), P(GAP304/12/0950), P(GPP207/10/P054), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	18
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Štěpánek, Petr Černoch, Peter Hrubý, Martin Kučka, Jan Škodová, Michaela Kaňková, Dana Chánová, Eliška Kálalová, Zuzana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	167338
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/12:00386090
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	chelates; nanoparticles; polymers (en)
http://linked.open.../riv/klicoveSlovo	polymers nanoparticles chelates
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[414A32A90BD3]
http://linked.open...i/riv/nazevZdroje	ChemPhysChem
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Chelating polymers as therapeuticals for Wilson´s disease Polymeric micelles with metal ion – assembled core Bioinspired nanoparticles sensitive to environment stimuli
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	13
http://linked.open...iv/tvurceVysledku	Hrubý, Martin Černoch, Peter Štěpánek, Petr Kučka, Jan Škodová, Michaela Kaňková, Dana Chánová, Eliška Kálalová, Zuzana
http://linked.open...ain/vavai/riv/wos	000313692600025
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	1439-4235
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/cphc.201200681
is http://linked.open...avai/riv/vysledek of	Self-assembled polymeric chelate nanoparticles as potential theranostic agents

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