About: Anthrapyrazole Antineoplastic Antibiotic     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Anthrapyrazole Antineoplastic Antibiotic
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Chemical Viewed Functionally
Preferred_Name
  • Anthrapyrazole Antineoplastic Antibiotic
UMLS_CUI
  • C1510919
Legacy_Concept_Name
  • Anthrapyrazole_Antibiotic
FULL_SYN
  • AnthrapyrazolesSYNCI
  • Anthrapyrazole Antineoplastic AntibioticPTNCI
DEFINITION
  • A class of antibiotics related to the anthracycline antineoplastic antibiotics. The anthrapyrazole antibiotics intercalate into DNA and interact with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. These agents may also block cell cycle division. In the presence of electron donors, some anthrapyrazole antibiotics cause single-strand breaks in DNA via photosensitization by visible light. These agents are less cardiotoxic than doxorubicin. (NCI04)NCI
code
  • C2107
is rdfs:subClassOf of
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