About: Piroxantrone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Piroxantrone
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Piroxantrone
NSC_Code
  • 349174
UMLS_CUI
  • C0069736
CAS_Registry
  • 91441-23-5
FDA_UNII_Code
  • YL4TY9WH22
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 40791
PDQ_Closed_Trial_Search_ID
  • 40791
Chemical_Formula
  • C21H25N5O4
Legacy_Concept_Name
  • Piroxantrone
FULL_SYN
  • PIROXANTRONEPTFDAYL4TY9WH22
  • OxantrazoleSYNCI
  • OxanthrazoleSYDTPNSC0349174
  • OxanthrazoleSYNCI
  • PiroxantronePTNCI
  • Piroxantrone HClSYNCI
  • Anthra(1,9-cd)pyrazol-6(2H)-one, 5-((3-aminopropyl)amino)-7,10-dihydroxy-2-(2-((2-hydroxyethyl)amino)ethyl)SNNCI
  • CI-942CNNCI
  • PD-111815CNNCI
DEFINITION
  • An anthrapyrazole antineoplastic antibiotic. Piroxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Although less cardiotoxic than doxorubicin, this agent exhibits a narrow spectrum of antineoplastic activity. (NCI04)NCI
code
  • C1182
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