About: Sedoxantrone Trihydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Sedoxantrone Trihydrochloride
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Sedoxantrone Trihydrochloride
NSC_Code
  • 635371
UMLS_CUI
  • C0281727
CAS_Registry
  • 119221-49-7
FDA_UNII_Code
  • X9GSL37ED0
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of some types of cancer. Sedoxantrone trihydrochloride binds to DNA and stops cells, including cancer cells, from repairing damage to DNA and from making more DNA, RNA, and protein. It is a type of DNA intercalator.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42217
PDQ_Closed_Trial_Search_ID
  • 42217
Chemical_Formula
  • C21H27N5OS.3ClH
Legacy_Concept_Name
  • Sedoxantrone_Trihydrochloride
FULL_SYN
  • LEDOXANTRONE TRIHYDROCHLORIDEPTFDAX9GSL37ED0
  • CI-958SYNCI-GLOSSCDR0000045429
  • 2H-(1)Benzothiopyrano(4,3,2-cd)indazol-8-ol, 5-((2-aminoethyl)amino)-2-(2-(diethylamino)ethyl)-, TrihydrochlorideSNNCI
  • CI 958CNNCI
  • CI-958CNNCI
  • Ledoxantrone TrihydrochlorideSYNCI
  • Sedoxantrone TrihydrochloridePTNCI
  • sedoxantrone trihydrochloridePTNCI-GLOSSCDR0000046059
DEFINITION
  • The trihydrochloride salt of the anthrapyrazole antineoplastic antibiotic sedoxantrone with potential antineoplastic activity. Sedoxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.NCI
code
  • C1576
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