About: Histone Deacetylase

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Histone Deacetylase
rdfs:subClassOf	Deacetylase nodeID://b680254 nodeID://b680255 nodeID://b680256 nodeID://b680257
Semantic_Type	Amino Acid, Peptide, or Protein Enzyme
Preferred_Name	Histone Deacetylase
UMLS_CUI	C0019643
ALT_DEFINITION	An enzyme that removes a small molecule called an acetyl group from histones (proteins found in chromosomes). This changes the way the histones bind to DNA and may affect its activity. HDAC inhibitors are being studied in the treatment of cancer.NCI-GLOSS
Legacy_Concept_Name	Histone_Deacetylase
FULL_SYN	HDACPTNCI-GLOSSCDR0000586370 histone deacetylasePTNCI-GLOSSCDR0000318815 HDACABNCI Histone DeacetylasePTNCI
DEFINITION	Histone acetylation and deacetylation alternately exposes and occludes DNA to transcription factors. Histone deacetylation is catalyzed by the histone deacetylases. There are at least 2 classes of HDACs, class I consisting of proteins homologous to yeast Rpd3 (e.g., HDAC1, HDAC2, and HDAC3) and class II consisting of proteins homologous to yeast Hda1 (e.g., HDAC4 and HDAC6). (from OMIM)NCI
code	C16682
sameAs	Histone Deacetylases
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0010420
is rdf:first of	nodeID://b732093 nodeID://b732094 nodeID://b732095 nodeID://b732096 nodeID://b732097 nodeID://b732098 nodeID://b732099 nodeID://b732100 nodeID://b732101 nodeID://b732102
is someValuesFrom of	nodeID://b666299 nodeID://b678014 nodeID://b680259 nodeID://b680278 nodeID://b680290 nodeID://b680297 nodeID://b680303 nodeID://b680312 nodeID://b680337 nodeID://b680350 nodeID://b689736 nodeID://b691147 nodeID://b698187 nodeID://b716172 nodeID://b720985 nodeID://b725198
is Has_Target of	VORINOSTAT Entinostat Mocetinostat Panobinostat PHENYLBUTYRATE SODIUM ROMIDEPSIN Belinostat Oral Sodium Phenylbutyrate Quisinostat
is sameAs of	Histone Deacetylases

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