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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Panobinostat
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Panobinostat
UMLS_CUI
  • C1566164
CAS_Registry
  • 404950-80-7
FDA_UNII_Code
  • 9647FM7Y3Z
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug being studied in the treatment of cancer. It blocks enzymes needed for cells to grow and divide and may kill cancer cells. Panobinostat may also prevent the growth of new blood vessels that tumors need to grow. It is a type of histone deacetylase inhibitor and a type of antiangiogenesis agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 530790
PDQ_Closed_Trial_Search_ID
  • 530790
Chemical_Formula
  • C21H23N3O2
Legacy_Concept_Name
  • LBH589
FULL_SYN
  • PANOBINOSTATPTFDA9647FM7Y3Z
  • (2E)-N-hydroxy-3-(4-(((2-(2-methyl-1h-indol-3-yl)ethyl)amino)methyl)phenyl)prop-2-enamideSNNCI
  • PanobinostatPTNCI
  • panobinostatPTNCI-GLOSSCDR0000637719
  • LBH589PTNCI-GLOSSCDR0000637718
  • LBH589CNNCI
  • FaridakPTNCI-GLOSSCDR0000637720
DEFINITION
  • A cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. HDAC is an enzyme that deacetylates chromatin histone proteins.NCI
code
  • C66948
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