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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Quisinostat
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Quisinostat
UMLS_CUI
  • C2703097
CAS_Registry
  • 875320-29-9
FDA_UNII_Code
  • 9BJ85K1J8S
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 596704
PDQ_Closed_Trial_Search_ID
  • 596704
Chemical_Formula
  • C21H26N6O2
Legacy_Concept_Name
  • HDAC_Inhibitor_JNJ-26481585
FULL_SYN
  • JNJ-26481585CNNCI
  • QuisinostatPTNCI
  • HDAC Inhibitor JNJ-26481585SYNCI
  • QUISINOSTATPTFDA9BJ85K1J8S
DEFINITION
  • An orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation.NCI
code
  • C77912
http://linked.open...y/mesh/hasConcept
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