About: Oral Sodium Phenylbutyrate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Oral Sodium Phenylbutyrate
rdfs:subClassOf
Has_Target
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Oral Sodium Phenylbutyrate
UMLS_CUI
  • C1882164
PDQ_Open_Trial_Search_ID
  • 41827
PDQ_Closed_Trial_Search_ID
  • 41827
Legacy_Concept_Name
  • Oral_Sodium_Phenylbutyrate
FULL_SYN
  • Oral Sodium PhenylbutyratePTNCI
DEFINITION
  • An orally active derivative of the short-chain fatty acid butyrate with potential antineoplastic activity. 4-Phenylbutyrate inhibits histone deacetylase, resulting in cell cycle gene expression modulation, reduced cell proliferation, increased cell differentiation, and apoptosis. This agent also initiates fragmentation of genomic DNA, resulting in decreased DNA synthesis and the inhibition of tumor cell migration and invasion.NCI
code
  • C67083
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