About: Mocetinostat     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Mocetinostat
rdfs:subClassOf
Has_Salt_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Mocetinostat
UMLS_CUI
  • C2002471
CAS_Registry
  • 726169-73-9
FDA_UNII_Code
  • A6GWB8T96J
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of several types of cancer. It blocks enzymes needed for cell division and may kill cancer cells. It is a type of histone deacetylase (HDAC) inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 486941
PDQ_Closed_Trial_Search_ID
  • 486941
Chemical_Formula
  • C23H20N6O
Legacy_Concept_Name
  • MGCD0103
FULL_SYN
  • MOCETINOSTATPTFDAA6GWB8T96J
  • MocetinostatPTNCI
  • N-(2-aminophenyl)-4-((4-pyridin-3-ylpyrimidin-2-ylamino)methyl)benzamideSNNCI
  • mocetinostatPTNCI-GLOSSCDR0000658785
  • MGCD0103PTNCI-GLOSSCDR0000630923
  • MG-0103CNNCI
  • MGCD0103CNNCI
  • Benzamide, N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]-SNNCI
DEFINITION
  • A rationally designed, orally available, Class 1-selective, small molecule, 2-aminobenzamide HDAC inhibitor with potential antineoplastic activity. Mocetinostat binds to and inhibits Class 1 isoforms of HDAC, specifically HDAC 1, 2 and 3, which may result in epigenetic changes in tumor cells and so tumor cell death; although the exact mechanism has yet to be defined, tumor cell death may occur through the induction of apoptosis, differentiation, cell cycle arrest, inhibition of DNA repair, upregulation of tumor suppressors, down regulation of growth factors, oxidative stress, and autophagy, among others. Overexpression of Class I HDACs 1, 2 and 3 has been found in many tumors and has been correlated with a poor prognosis.NCI
code
  • C62521
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