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| Description
| - I. Experimental study of biochemical, cellular and molecular biology aspects of cell differentiation and neoplastic transformation, their use in advenced diagnostics, prognosis and therapy of tumours.II. Biological factors influencing the clinical courseof hematooncological diseases and new methods of therapyIII. Study of hereditary and sporadic breast/ovarian cancersIV. Molecular genetic and cytogenetic characteristics of selected hereditary and sporadic tumours in the relation to early diagnosis, prognosis and therapy (en)
- Práce na navrhovaném projektu má přinést nové poznatky z oblasti buněčné a molekulární biologie a fyziologie, důležité jak z hlediska základního výzkumu (poznání některých regulačních mechanismů růstu, diferenciace a transformace buněk) tak i kliniky (buněk na cytostatickou léčbu).Výsledky výzkumného záměru mají umožnit identifikaci molekulárních cílů a buněčných regulačních procesů, umožňujících predikci, časnou diagnostiku, průběžné sledování rozvoje onemocnění a specifický a individualisovaný přía solidních neoplasií. Dalším cílem je též návrh nových biologicky aktivních látek interferujících s nádorovou progresí, jak na úrovni samotné transformované buňky, tak i ovlivněním imunitního systému. Spolupráce teoretických a klinických pracovišť několumožňuje komplexní multidisciplinární přístup řešení výzkumného záměru.
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| Title
| - Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu
- Molecular biological, genetic and epigenetic aspects of development of model tumors. Relation to epidemiology, early diagnostics and therapy. (en)
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ez/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...vavai/cez/dodavka
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| http://linked.open...ez/duvernostUdaju
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| http://linked.open...in/vavai/cez/faze
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| http://linked.open...ai/cez/hlavniObor
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| http://linked.open...vai/cez/hodnoceni
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| http://linked.open.../cez/kategorieVaV
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| http://linked.open.../cez/klicovaSlova
| - model tumors; epidemiology; early diagnostics; therapy (en)
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| http://linked.open...cez/partnerHlavni
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| http://linked.open...z/poceVysledkuRIV
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cez/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open.../vavai/cez/resort
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ez/ukonceniReseni
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| http://linked.open...ez/zahajeniReseni
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| http://linked.open...n/vavai/cez/zamer
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| http://linked.open...sledkuDodavatelem
| - VZ přinesl nové poznatky u solidních i hematologických nádorů od úrovně základního výzkumu až po jejich klinické využití. Umožnil spolupráci všech LF UK, ÚHKT i AV. Výsledkem je 231 článků v časopisech s IF, 1 patent a 574 citací, 8 prof., 6 doc. řízení a 37 PhD. Finanční prostředky byly čerpány v souladu s plánem. Byla vyvinuta a je testována látka s protinádorovým působením. (cs)
- The project extended knowledge in solid and hematological tumors from basic to clinical research. The funds allowed successful collaboration of Charles University Medical Faculties, IHBT and Academy of Science. 231 papers were published in IF journals; 8 Prof.; 6 Assoc. Prof.; and 37 Phd. titles and several prestigious awards were obtained. A new substance with anticancer effect was developed. (en)
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| http://linked.open...cez/zivotniCyklus
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| is http://linked.open...n/vavai/riv/zamer
of | - Phosphoenolpyruvate carboxylase, NADP-malic enzyme, and pyruvate, phosphate dikinase are involved in the acclimation of Nicotiana tabacum L. to drought stress
- Establishment, growth and in vivo differentiation of a new clonal human cell line, EM-G3
- Isolation of cytoplasmic NADPH-dependent phenol hydroxylase and catechol-1,2-dioxygenase from Candida tropicalis yeast
- Isolation and partial characterization of catechol 1,2-dioxygenase of phenol degrading yeast Candida tropicalis
- Respirometry Kinetics of Phenol Oxidation by Comamonas testosteroni Pb50 under Various Conditions of Nutritional Stress
- Humoral response against Mycobacterium bovis Hsp65 derived fragments in children and young people with various disorders
- Orbitální tumory u dospělých - desetiletá studie
- The correlation between echographic and histopathological findings in uveal melanoma
- Leiomyom přední stěny břišní
- DNA repair genetic polymorphisms and risk of colorectal cancer in the Czech Republic
- Karcinom z Merkelových buněk - Imunohistologická studie v souboru 11 pacientů
- Expression of class III beta-tubulin in colorectal carcinomas: an immunohistochemical study using TU-20 & TuJ-1 antibody
- Cytokeratins 8 and 18 in adult human corneal endothelium
- Neuroendokrinní nádory trávicího ústrojí - historie a současnost
- An unusual triple-negative breast carcinoma
- Předpoklady pro preimplantační genetickou diagnostiku (PGD) u nosičů mutací v nádorových predispozičních genech
- The role of SRc-3 in human breast cancer
- Účinek rázové vlny na kostní cement a její potenciální využití v ortopedii
- 5-Azacitidine in aggressive myelodysplastic syndromes regulates chromatin structure at PU.1 gene and cell differentiation capacity
- Factors influencing arterial stiffness in pheochromocytoma and effect of adrenalectomy
- Acyklické nukleosidfosfonáty jako potenciální antineoplastika
- Redox cycling in the metabolism of the environmental pollutant and suspected human carcinogen o-anisidine by rat and rabbit hepatic microsomes
- A one-electron oxidation of carcinogenic nonaminoazo dye Sudan I by horseradish peroxidase
- In Vivo Modulation of Angiogenic Genes Expression by Acyclic Nucleoside Phosphonates PMEDAP and PMEG
- Mechanism of formation of (deoxy)guanosine adducts derived from peroxidase-catalyzed oxidation of the carcinogenic nonaminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I)
- The cultivation of human multipotent mesenchymal stromal cells in clinical grade medium for bone tissue engineering
- TRAIL-induced apoptosis of HL60 leukemia cells: Two distinct phenotypes of acquired TRAIL resistance that are accompanied with resistance to TNFa but not to idarubicin and cytarabine
- The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies
- Regulation of phosphoenolpyruvate carboxylase in PVYNTN-infected tobacco plants
- The regulation and catalytic mechanism of the NADP-malic enzyme from tobacco leaves
- Effect of Potato Virus Y on the NADP-Malic Enzyme from Nicotiana tabacum L.: mRNA, Expressed Protein and Activity
- Characterization of phosphoenolpyruvate carboxylase from mature maize seeds: Properties of phosphorylated and dephosphorylated forms
- Monitoring of dimethyl sulphate-induced N3-methyladenine, N7-methylguanine and O6-methylguanine DNA adducts using reversed-phase high performance liquid chromatography and mass spectrometry
- Modulation of cytochrome P450 enzyme system by selected flavonoids
- Oxidation of the carcinogenic non-aminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I) by cytochromes P450 and peroxidases: a comparative study
- Chemopreventive compounds-View from the other side
- Analysis of benzo[a]pyrene metabolites formed by rat hepatic microsomes using high pressure liquid chromatography: optimization of the method
- Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)-hydroxylamine with deoxyguanosine in DNA
- Oxidation of 3-aminobenzanthrone, a human metabolite of carcinogenic environmental pollutant 3-nitrobenzanthrone, by cytochromes P450 ? similarity between human and rat enzymes
- A role of biotransformation enzymes in the Development of renal injury and urothelial cancer caused by aristolochic acid: Urgent questions difficult answers
- Rat cytochromes P450 oxidize 2-nitrophenol, a human metabolite of carcinogenic 2-nitroanisole
- Preparation of a biologically active apo-cytochrome b5 via heterologous expression in Escherichia coli
- Preparation of apo-cytochrome b5 utilizing heme transfer to apo-myoglobin
- 3-Aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone, induces biotransformation enzymes in rat kidney and lung
- Cytotoxicity of and DNA adduct formation by ellipticine in human U87MG glioblastoma cancer cells
- Linear Energy Relationships for the Octahedral Preference of Mg, Ca and Transition Metal Ions
- Fungal nitrilases as biocatalysts: Recent developments
- Glycosidases: a key to tailored carbohydrates
- Antitumor Effects and Cytotoxicity of Recombinant Plant Nucleases
- Enzymy Hatchova-Slackova cyklu v C3 rostlinách
- Cytochrome P450 3A activities and their modulation by alfa-naphthoflavone in vitro are dictated by the efficiencies of model experimental systems
- Identification of human enzymes oxidizing a human metabolite of carcinogenic 2-nitroanisole, 2-nitrophenol. Evidence for its oxidative detoxification by human cytochromes P450.
- Mechanisms of the different DNA adduct forming potentials of the urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone
- Rat liver microsomal metabolism of o-aminophenol and N-(2-methoxyphenyl)hydroxylamine, two metabolites of the environmental pollutant and carcinogen o-anisidine in humans
- Molekulárně cytogenetická charakteristika feochromocytomu
- Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney
- Identification of rat cytochromes P450 metabolizing N-(2-methoxyphenyl)hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o- nitroanisole
- ANALYTICKÁ ULTRACENTRIFUGA A JEJÍ VYUŽITÍ V BIOCHEMICKÉ LABORATOŘI
- AVENUES OF THE CONTEMPORARY GLYCOSCIENCE: FROM GLYCOMIC TECHNOLOGIES TO DRUGS THAT ARE SWEET INSIDE AS WELL AS AT THE SURFACE
- %22Transcription physiology%22 of pigment formation in melanocytes: central role of MITF.
- Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial.
- Preemptivní antimykotická léčba febrilní neutropenie u nemocných s hematologickou malignitou - změna dosavadní strategie léčby invazivních mykotických onemocnění?
- CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer
- Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma
- The evaluation of survival and proliferation of lymphocytes in autologous mixed leukocyte reaction with dendritic cells. The comparison of incorporation of 3H-thymidine and differential gating method
- Ellipticine cytotoxicity to cancer cell lines-a comparative study
- Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors
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