About: AVENUES OF THE CONTEMPORARY GLYCOSCIENCE: FROM GLYCOMIC TECHNOLOGIES TO DRUGS THAT ARE SWEET INSIDE AS WELL AS AT THE SURFACE     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • Introduction:Changes in cell surface glycosylation accompanies diseases such as inflammation, rheumatoid arthritis, and malignant transformations. These changes are supposed to be monitored by carbohydrate receptors of lectin type on the surface of cells of the immune system. However, the exact nature of these receptors orchestrating such reactions remains elusive. Methods: We used a panel of recombinant lectin-like receptors of killer lymphocytes, bioaffinity techniques, oligosaccharide arrays, and mass spectrometry to analyze the complete oligosaccharide profiles responsible for sensitivity of tumor cells for natural killing and apoptosis. Results: Highly branched N-linked oligosaccharides recognized by NKR-P1 and NKG2D receptors were linked to sensitivity to natural killing. On the other hand, clustered O-linked oligosaccharides cross-linking CD69 receptors were able to cause the apoptotic death of the activated killer lymphocytes. Conclusions: We were able to identify classes of surface oligosaccharides responsible for natural killing of tumor cells as well as for the ability of tumors to eliminate the killer lymphocytes.
  • Introduction:Changes in cell surface glycosylation accompanies diseases such as inflammation, rheumatoid arthritis, and malignant transformations. These changes are supposed to be monitored by carbohydrate receptors of lectin type on the surface of cells of the immune system. However, the exact nature of these receptors orchestrating such reactions remains elusive. Methods: We used a panel of recombinant lectin-like receptors of killer lymphocytes, bioaffinity techniques, oligosaccharide arrays, and mass spectrometry to analyze the complete oligosaccharide profiles responsible for sensitivity of tumor cells for natural killing and apoptosis. Results: Highly branched N-linked oligosaccharides recognized by NKR-P1 and NKG2D receptors were linked to sensitivity to natural killing. On the other hand, clustered O-linked oligosaccharides cross-linking CD69 receptors were able to cause the apoptotic death of the activated killer lymphocytes. Conclusions: We were able to identify classes of surface oligosaccharides responsible for natural killing of tumor cells as well as for the ability of tumors to eliminate the killer lymphocytes. (en)
Title
  • AVENUES OF THE CONTEMPORARY GLYCOSCIENCE: FROM GLYCOMIC TECHNOLOGIES TO DRUGS THAT ARE SWEET INSIDE AS WELL AS AT THE SURFACE
  • AVENUES OF THE CONTEMPORARY GLYCOSCIENCE: FROM GLYCOMIC TECHNOLOGIES TO DRUGS THAT ARE SWEET INSIDE AS WELL AS AT THE SURFACE (en)
skos:prefLabel
  • AVENUES OF THE CONTEMPORARY GLYCOSCIENCE: FROM GLYCOMIC TECHNOLOGIES TO DRUGS THAT ARE SWEET INSIDE AS WELL AS AT THE SURFACE
  • AVENUES OF THE CONTEMPORARY GLYCOSCIENCE: FROM GLYCOMIC TECHNOLOGIES TO DRUGS THAT ARE SWEET INSIDE AS WELL AS AT THE SURFACE (en)
skos:notation
  • RIV/00216208:11310/10:10109497!RIV12-GA0-11310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GD305/09/H008), Z(MSM0021620808)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 248289
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11310/10:10109497
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • glycosylation; NKR-P1; receptor; carbohydrate; in-vivo; e-selectin; missing self; oligosaccharide ligand; glycan-binding-proteins; killer-cell activation (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [16FF28BDB9D2]
http://linked.open...v/mistoKonaniAkce
  • Prague, CZECH REPUBLIC
http://linked.open...i/riv/mistoVydani
  • Novotného Lávka 5, Prague, CZECH REPUBLIC
http://linked.open...i/riv/nazevZdroje
  • Proceedings of the 6th international conference on polysaccharides-glycoscience
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Bezouška, Karel
http://linked.open...vavai/riv/typAkce
http://linked.open...ain/vavai/riv/wos
  • 000287421800001
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • Czech chemical society
https://schema.org/isbn
  • 978-80-86238-78-4
http://localhost/t...ganizacniJednotka
  • 11310
is http://linked.open...avai/riv/vysledek of
Faceted Search & Find service v1.16.116 as of Feb 22 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3239 as of Feb 22 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 80 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software