About: %22Transcription physiology%22 of pigment formation in melanocytes: central role of MITF.

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: %22Transcription physiology%22 of pigment formation in melanocytes: central role of MITF. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Melanin production is the primary mechanism protecting human skin against the UV light-induced damage. The transcription factor MITF, which has been reported to activate more than 25 genes in pigment cells, has emerged as an essential regulator not only for melanocyte development, proliferation and survival, but also for the expression of enzymes and structural proteins ensuring the production of melanin. Here, we outline the mechanisms of transcriptional regulation of genes associated with the biosynthesis of melanin in melanocytes and melanoma cells. MITF is crucial in this process, while several other factors seem to have only an auxiliary role to play under specific circumstances. Melanin production is the primary mechanism protecting human skin against the UV light-induced damage. The transcription factor MITF, which has been reported to activate more than 25 genes in pigment cells, has emerged as an essential regulator not only for melanocyte development, proliferation and survival, but also for the expression of enzymes and structural proteins ensuring the production of melanin. Here, we outline the mechanisms of transcriptional regulation of genes associated with the biosynthesis of melanin in melanocytes and melanoma cells. MITF is crucial in this process, while several other factors seem to have only an auxiliary role to play under specific circumstances. (en)
Title	%22Transcription physiology%22 of pigment formation in melanocytes: central role of MITF. %22Transcription physiology%22 of pigment formation in melanocytes: central role of MITF. (en)
skos:prefLabel	%22Transcription physiology%22 of pigment formation in melanocytes: central role of MITF. %22Transcription physiology%22 of pigment formation in melanocytes: central role of MITF. (en)
skos:notation	RIV/00064211:_____/10:#0000066!RIV11-MZ0-00064211
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(NR9319), S, Z(MSM0021620808)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Vachtenheim, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Nemocnice Na Bulovce
http://linked.open...dnocenehoVysledku	293275
http://linked.open...ai/riv/idVysledku	RIV/00064211:_____/10:#0000066
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	melanin; melanoma; microphthalmia; microphthalmia-associated transcription factor; pigmentation (en)
http://linked.open.../riv/klicoveSlovo	microphthalmia-associated transcription factor microphthalmia melanoma melanin pigmentation
http://linked.open...odStatuVydavatele	DK - Dánské království
http://linked.open...ontrolniKodProRIV	[9A495ABD39D7]
http://linked.open...i/riv/nazevZdroje	Experimental dermatology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Altered function and composition of the chromatin-remodeling complex SWI/SNF in the progression of lung carcinoma and melanoma
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Borovanský, Jan Vachtenheim, Jiří
http://linked.open...n/vavai/riv/zamer	Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu
issn	0906-6705
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	"Transcription physiology" of pigment formation in melanocytes: central role of MITF. %22Transcription physiology%22 of pigment formation in melanocytes: central role of MITF. %22Transcription physiology%22 of pigment formation in melanocytes: central role of MITF.

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 12 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software