About: CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer

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About: CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Checkpoint kinase 2 gene (CHEK2) alterations increase risk of several cancer types. We analyzed selected CHEK2 alterations in 270 Czech pancreatic cancer patients and in 683 healthy controls. The pancreatic cancer risk was higher in individuals who inherited rare alterations in CHEK2 region involving forkhead-associated domain other than I157T (OR = 5.14; 95% Cl = 0.94-28.23) but the observed association was non-significant (p = 0.057). The most frequent I157T mutation did not alter the pancreatic cancer risk and neither the followed deletion of 5395 bp nor c.1100delC were found in any of pancreatic cases. We conclude that the I157T, other alterations in its proximity, del5395 and c.1100delC in CHEK2 do not predispose to pancreatic cancer risk in the Czech population. Checkpoint kinase 2 gene (CHEK2) alterations increase risk of several cancer types. We analyzed selected CHEK2 alterations in 270 Czech pancreatic cancer patients and in 683 healthy controls. The pancreatic cancer risk was higher in individuals who inherited rare alterations in CHEK2 region involving forkhead-associated domain other than I157T (OR = 5.14; 95% Cl = 0.94-28.23) but the observed association was non-significant (p = 0.057). The most frequent I157T mutation did not alter the pancreatic cancer risk and neither the followed deletion of 5395 bp nor c.1100delC were found in any of pancreatic cases. We conclude that the I157T, other alterations in its proximity, del5395 and c.1100delC in CHEK2 do not predispose to pancreatic cancer risk in the Czech population. (en)
Title	CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer (en)
skos:prefLabel	CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer (en)
skos:notation	RIV/00216224:14110/10:00051816!RIV12-MSM-14110___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(NS9799), Z(MSM0021620808), Z(MZ0MOU2005)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Foretová, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	250536
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00051816
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Checkpoint kinase 2; Alterations; Deletion; Pancreatic cancer; Risk (en)
http://linked.open.../riv/klicoveSlovo	Pancreatic cancer Risk Alterations Checkpoint kinase 2 Deletion
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[A86D7AADBA5F]
http://linked.open...i/riv/nazevZdroje	Cancer epidemiology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of relation between expression profiles in tumor tissue and result of chemotherapy of breast carcinomas
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	34
http://linked.open...iv/tvurceVysledku	Foretová, Lenka Kleibl, Zdeněk Pohlreich, Petr Souček, Pavel Mohelníková-Duchoňová, B. Havránek, O. Hlavata, I.
http://linked.open...ain/vavai/riv/wos	000283974700024
http://linked.open...n/vavai/riv/zamer	Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu Functional diagnostics of malignant tumours
issn	1877-7821
number of pages	3 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.canep.2010.06.008
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer

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