About: Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation

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About: Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This research article is first report of the role of spastin in cell motility. The enzyme spastin is from microtubule-severing ATPases and regulates lenght of microtubules. Among strategies used for treating malignant tumors belongs disrupting the integrity of microtubules. The role of microtubules on invasivity has the higher propensity especially in glioblastoma cells from brain. To find the answer to question, if spastin and microtubules regulation somehow influence each other, spastin expression evaluation and testing of intracellular distribution was performed in human glioblastomas and astrocytes. It was found that spastin expression is increased in tumor cells. Surprisingly, functional experiments comparing the effects of spastin depletion on the motility and proliferation in glioblastomas have shown decreased motility and higher proliferation rate. The article proposes that spastin in glioblastomas might be linked to tumor cell invasion. This research article is first report of the role of spastin in cell motility. The enzyme spastin is from microtubule-severing ATPases and regulates lenght of microtubules. Among strategies used for treating malignant tumors belongs disrupting the integrity of microtubules. The role of microtubules on invasivity has the higher propensity especially in glioblastoma cells from brain. To find the answer to question, if spastin and microtubules regulation somehow influence each other, spastin expression evaluation and testing of intracellular distribution was performed in human glioblastomas and astrocytes. It was found that spastin expression is increased in tumor cells. Surprisingly, functional experiments comparing the effects of spastin depletion on the motility and proliferation in glioblastomas have shown decreased motility and higher proliferation rate. The article proposes that spastin in glioblastomas might be linked to tumor cell invasion. (en)
Title	Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation (en)
skos:prefLabel	Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation (en)
skos:notation	RIV/68378050:_____/11:00365459!RIV12-AV0-68378050
http://linked.open...avai/predkladatel	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/09/1777), P(GAP302/10/1701), P(GD204/09/H084), P(KAN200520701), P(LC545), Z(AV0Z50110509), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vinopal, Stanislav Dráber, Pavel Sládková, Vladimíra Dráberová, Eduarda Sulimenko, Tetyana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	212395
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00365459
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	spastin; glioblastoma; cell motility (en)
http://linked.open.../riv/klicoveSlovo	glioblastoma cell motility spastin
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[8DA6B8E46865]
http://linked.open...i/riv/nazevZdroje	Journal of Neuropathology and Experimental Neurology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	16 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional Organisation of the Cell Molecular biology of a differentiating cell Nano-PCR - ultrasensitive test for detection of specific proteins in body fluids Analysis of signaling assemblies containing gamma-tubulin Analysis of functional differences between gamma-tubulins
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	70
http://linked.open...iv/tvurceVysledku	Janáček, Jiří Sládková, Vladimíra Baas, P. Burns, M. R. De Chadarévian, J. P. Dráber, Pavel Dráberová, Eduarda Katsetos, C. D. Kulandaivel, K. Legido, A. Liu, P. S. Morfini, G. Mork, S. J. Solowska, J. Sulimenko, Tetyana Vinopal, Stanislav
http://linked.open...ain/vavai/riv/wos	000294247700008
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0022-3069
number of pages	16 (xsd:int)
http://bibframe.org/vocab/doi	10.1097/NEN.0b013e31822c256d
is http://linked.open...avai/riv/vysledek of	Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation

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