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Description
  • Gamma-tubulin is involved in the nucleation of microtubules from microtubule organizing centers. Recent data document that gamma-tubulin is also associated with membranes and interacts with Src family protein tyrosine kinase Fyn and p85? regulatory subunit of phosphoinositide 3-kinase (PI3K), that are involved in signal transduction. The aim of this research project is to elucidate the role of Fyn and PI3K in regulation of gamma-tubulin functions in mast cell signaling. To this end we will characterize protein complexes containing gamma-tubulin and signaling molecules, prepare p85? functional domains and their parts for pull down assays, and analyze gamma-tubulin forms in activated cells. Immunofluorescence microscopy and live cell imaging will be used for evaluation of microtubule nucleation and microtubule dynamics in cells. Both wild-type cells and cells with kinases silenced by RNAi will be used. These studies could lead to a better understanding of gamma-tubulin functions in normal cells and under various disease conditions. (en)
  • Cílem tohoto projektu je pomocí molekulárně biologických přístupů a mikroskopických technik porozumět úloze klíčových signálních molekul při regulaci nukleace mikrotubulů v průběhu aktivace žírných buněk. Studium povede k hlubšímu pochopení tvorby mikrotubulů za normálních a patologických stavů.
Title
  • Analysis of signaling assemblies containing gamma-tubulin (en)
  • Analýza signálních komplexů obsahujících gama-tubulin
skos:notation
  • GA204/09/1777
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  • cytoskelet; gama-tubulin; regulace nukleace mikrotubulů; kinázy (en)
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  • Řešení projektu proběhlo výtečně, jak z hlediska odborného tak i z hlediska čerpání finančních prostředků. (cs)
  • The project was excellent, both in terms of expertise and in terms of disbursement of funds. (en)
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  • gama-tubulin
  • regulace nukleace mikrotubulů
  • cytoskelet
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