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Description
  • Pro odhalení renálně exprimovaných genů, které ovlivňují riziko vývinu hypertenze, jsme integrovali eQTL analýzy s celogenomovými korelačními analýzami profilů genové exprese v ledvině s krevním tlakem u rekombinantních inbredních kmenů, odvozených od spontánně hypertenzních potkanů kmene SHR. Tato strategie, společně s transplantacemi ledvin u SHR, SHR kongenních a transgenních kmenů, umožnila identifikaci deficitní exprese Cd36 genu, kódujícího translokázu mastných kyselin, jako genetické determinanty spontánní hypertenze (cs)
  • To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension
  • To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension (en)
Title
  • Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension
  • Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension (en)
  • Identifikace renálního Cd36 jako determinanty krevního tlaku a rizika hypertenze (cs)
skos:prefLabel
  • Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension
  • Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension (en)
  • Identifikace renálního Cd36 jako determinanty krevního tlaku a rizika hypertenze (cs)
skos:notation
  • RIV/67985823:_____/08:00311214!RIV09-MZ0-67985823
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0520), P(1P05ME791), P(IAA500110604), P(IAA500110805), P(ME08006), P(NR8495), P(NR8545), P(NR9359), P(NR9387), Z(AV0Z50110509), Z(MSM0021620807)
http://linked.open...iv/cisloPeriodika
  • 8
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 371245
http://linked.open...ai/riv/idVysledku
  • RIV/67985823:_____/08:00311214
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • spontaneously hypertensive rat; Cd36; hypertension (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [99730DDB680B]
http://linked.open...i/riv/nazevZdroje
  • Nature Genetics
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 40
http://linked.open...iv/tvurceVysledku
  • Kazdová, L.
  • Křen, Vladimír
  • Kurtz, T. W.
  • Landa, Vladimír
  • Maxová, M.
  • Mlejnek, Petr
  • Pravenec, Michal
  • Wang, J.
  • Zídek, Václav
  • Hubner, N.
  • Petretto, E.
  • Aitman, T. J.
  • Bidani, A.
  • Churchill, M. C.
  • Churchill, P. C.
  • Dunbar, J.
  • Griffin, K.
  • Qi, N.
  • Vyklický, O.
  • Wallace, C. A.
  • Zimdahl, H.
http://linked.open...ain/vavai/riv/wos
  • 258026900010
http://linked.open...n/vavai/riv/zamer
issn
  • 1061-4036
number of pages
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