About: Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Pro odhalení renálně exprimovaných genů, které ovlivňují riziko vývinu hypertenze, jsme integrovali eQTL analýzy s celogenomovými korelačními analýzami profilů genové exprese v ledvině s krevním tlakem u rekombinantních inbredních kmenů, odvozených od spontánně hypertenzních potkanů kmene SHR. Tato strategie, společně s transplantacemi ledvin u SHR, SHR kongenních a transgenních kmenů, umožnila identifikaci deficitní exprese Cd36 genu, kódujícího translokázu mastných kyselin, jako genetické determinanty spontánní hypertenze (cs) To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension (en)
Title	Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension (en) Identifikace renálního Cd36 jako determinanty krevního tlaku a rizika hypertenze (cs)
skos:prefLabel	Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension (en) Identifikace renálního Cd36 jako determinanty krevního tlaku a rizika hypertenze (cs)
skos:notation	RIV/67985823:_____/08:00311214!RIV09-MZ0-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0520), P(1P05ME791), P(IAA500110604), P(IAA500110805), P(ME08006), P(NR8495), P(NR8545), P(NR9359), P(NR9387), Z(AV0Z50110509), Z(MSM0021620807)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Zídek, Václav Mlejnek, Petr Landa, Vladimír Pravenec, Michal Křen, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	371245
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/08:00311214
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	spontaneously hypertensive rat; Cd36; hypertension (en)
http://linked.open.../riv/klicoveSlovo	spontaneously hypertensive rat hypertension - ischaemic heart disease - cardiac failure - vitamin D Cd36
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[99730DDB680B]
http://linked.open...i/riv/nazevZdroje	Nature Genetics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	21 (xsd:int)
http://linked.open...vavai/riv/projekt	Positional cloning of a gene on chromosome 10 that is responsible for hypertension and metabolic defects in the spontaneously hypertensive rat Pathophysiology and genetics of metabolic syndrome in experimental models and humans The role of adipocytokines and fatty acids in the disorders of insulin sensitivity and insulin secretion in metabolic syndrome Center for Applied Genomics Mechanisms and consequences of tissue triglyceride and fatty acid derivatives accumulation in insulin resistance - a possible impact of hypolipidemic therapy. Pathophysiological mechanisms of spontaneous hypertension and salt sensitivity Analysis of mechanisms of adipokine autocrine effects on glucose and lipid metabolism Genetic and correlation analyses of ectopic fat accumulation and adipose tissue oxidative/inflammatory processes and their role in the pathogenesis of insulin resistance Pathogenesis of spontaneous hypertension: integrated analysis of intermediary phenotypes of autonomic/sympathetic system and gene expression profiles in rat recombinant inbred strains
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	40
http://linked.open...iv/tvurceVysledku	Kazdová, L. Křen, Vladimír Kurtz, T. W. Landa, Vladimír Maxová, M. Mlejnek, Petr Pravenec, Michal Wang, J. Zídek, Václav Hubner, N. Petretto, E. Aitman, T. J. Bidani, A. Churchill, M. C. Churchill, P. C. Dunbar, J. Griffin, K. Qi, N. Vyklický, O. Wallace, C. A. Zimdahl, H.
http://linked.open...ain/vavai/riv/wos	258026900010
http://linked.open...n/vavai/riv/zamer	Metabolické, endokrinní a genetické aspekty prevence, diagnostiky a terapie kardiovaskulárních, cerebrovaskulárních a renovaskulárních onemocnění Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	1061-4036
number of pages	3 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension

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