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rdf:type
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Description
| - Pro odhalení renálně exprimovaných genů, které ovlivňují riziko vývinu hypertenze, jsme integrovali eQTL analýzy s celogenomovými korelačními analýzami profilů genové exprese v ledvině s krevním tlakem u rekombinantních inbredních kmenů, odvozených od spontánně hypertenzních potkanů kmene SHR. Tato strategie, společně s transplantacemi ledvin u SHR, SHR kongenních a transgenních kmenů, umožnila identifikaci deficitní exprese Cd36 genu, kódujícího translokázu mastných kyselin, jako genetické determinanty spontánní hypertenze (cs)
- To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension
- To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension (en)
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Title
| - Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension
- Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension (en)
- Identifikace renálního Cd36 jako determinanty krevního tlaku a rizika hypertenze (cs)
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skos:prefLabel
| - Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension
- Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension (en)
- Identifikace renálního Cd36 jako determinanty krevního tlaku a rizika hypertenze (cs)
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skos:notation
| - RIV/67985823:_____/08:00311214!RIV09-MZ0-67985823
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1M0520), P(1P05ME791), P(IAA500110604), P(IAA500110805), P(ME08006), P(NR8495), P(NR8545), P(NR9359), P(NR9387), Z(AV0Z50110509), Z(MSM0021620807)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/08:00311214
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - spontaneously hypertensive rat; Cd36; hypertension (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Kazdová, L.
- Křen, Vladimír
- Kurtz, T. W.
- Landa, Vladimír
- Maxová, M.
- Mlejnek, Petr
- Pravenec, Michal
- Wang, J.
- Zídek, Václav
- Hubner, N.
- Petretto, E.
- Aitman, T. J.
- Bidani, A.
- Churchill, M. C.
- Churchill, P. C.
- Dunbar, J.
- Griffin, K.
- Qi, N.
- Vyklický, O.
- Wallace, C. A.
- Zimdahl, H.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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is http://linked.open...avai/riv/vysledek
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