About: Human genome structure

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
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rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=IAA5004306
Description	One of the main directions of human genome research in the post-genomic eta is the study of its higher-order structure that became the key to understanding of the most important cellular processes such as cell differentiation or transformation. Using high-resolution cytometry developed in our laboratory, nuclear and territorial topography of genetic elements will be systematically investigated in normal and malignant human cell types. The topography and its changel will be correlated with local acetylation of histones, methylation of DNA and expression of gene clusters. In addition, changes of the structure of chromosome terriories or whole human genome in the cell nucleus during differentiation and cancerogenesis will be determined and an attempt will be made to find the basic psrinciples of the epigenetic regulation of gene expression. The practical goal of the project is the use of experimental results and technology developed in our laboratory in diagnostics ant therapy of cancer. (en) Po rozluštění genetického kódu je jedním z hlavních směrů výzkum lidského genomu studium jeho struktury vyššího řádu, které se stalo klíčem k pochopení nejdůležitějších buněčných procesů jako je diferenciace či transformace buňky. V tomto projektu bude systematicky zkoumána jaderná a teritoriální ropografie různých genetických elementů ve zdravých i nádorových buňkách s využitím cytometrie s vysokým rozlišením, vyvinuté v naší laboratoři. Topografie a její změny budou korelovány s lokální acetylací histonů, metylací DNA a expresí genových klastrů. Kromě toho budou studovány změny struktury chromosomových teritorií a buněčného jádra během diferenciace a kancerogeneze. Na základě získaných poznatků se budeme snažit o nalezení základních principů epigenetické regulace exprese genů. Praktickým cílem projektu bude využití získaných poznatků v diagnostice a při léčbě nádorových onemocnění.
Title	Human genome structure (en) Struktura lidského genomu
skos:notation	IAA5004306
http://linked.open...avai/cep/aktivita	Grants of distinctly investigative character focused on the sphere of research pursued at present particularly in the Academy of Sciences of the Czech Republic
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/IAA5004306/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/IAA5004306/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2013-06-28 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	71727880
http://linked.open...ai/cep/hlavniObor	EB - Genetika a molekulární biologie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	nuclear architecture; chromosome structure; FISH; high-resolution cytometry (en)
http://linked.open...ep/partnetrHlavni	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...inujicichPrijemcu	1 (xsd:int)
http://linked.open...cep/pocetPrijemcu	2 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	44 (xsd:int)
http://linked.open...enychVysledkuVRIV	44 (xsd:int)
http://linked.open...lneniVMinulemRoce	2007-02-27 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/IAA5004306
http://linked.open...iciPoslednihoRoku	2007
http://linked.open...atUdajeProjZameru	2008
http://linked.open.../vavai/cep/soutez	SAV02003-A
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2007-12-01 (xsd:date)
http://linked.open.../cep/vedlejsiObor	FD - Onkologie a hematologie
http://linked.open...ep/zahajeniReseni	2003-01-01 (xsd:date)
http://linked.open...jektu+dodavatelem	In the project, we have investigated the arrangement of the human genome. Correlation between the arrangement of the genome and its function, particularly transcription, has been found. A model of the genome arrangement has been proposed. (en) V rámci projektu jsme se zabývali strukturou lidského genomu. Byla získána řada významných výsledků svědčících o tom, že funkce geonomu, zejména jeho transkripce, koreluje s jeho uspořádáním v jádře buňky a byl navržen model tohoto uspořádání genomu. (cs)
http://linked.open...tniCyklusProjektu	ZBBBKU
http://linked.open.../cep/klicoveSlovo	FISH chromosome structure nuclear architecture
is http://linked.open...vavai/riv/projekt of	Cytological study of DNA methylation and histone methylation patterns in human cell lines Different nuclear localization of aberrant and normal chromosome 8 homologues in intact or NaBt differentiated HT-29 cells Different nuclear localization of aberrant and normal chromosome 8 homologues in intact of NaBt differentiated HT-29 cells From Jenalumar to ultrafast microscopy of living cells Gene expression in colorectal carcinoma determined by cDNA microarrays using a combination of several evaluation approaches Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci New insights into gene positional clustering and its properties supported by large-scale analysis of various differentiation pathways Analysis of biomedical image data acquired using optical microscopy Cytogenetics and cytology of retinoblastomas Chromosomal territory segmentation in apoptotic cells Detailed studies of the human genome 3D structure Image analysis of the movement of sub-cellular structures H3K9 Acetylation and Radial Chromatin Positioning Nuclear and territorial topography of chromosome telomeres in human lymphocytes Nuclear topography of beta-like globin gene cluster in IL-3-stimulated human leukemic K-562 cells Fast Point-Based 3D Alignment of Live Cells Comparative transcriptome maps: a new approach to the diagnosis of colorectal carcinoma patients using cDNA microarrays Statistical techniques for edge detection in histological images Localization of genetic elements of intact and derivative chromosome 11 and 22 territories in nuclei of Ewing sarcoma cells Nuclear topography and expression of the BCR/ABL fusion gene and its protein level influenced by cell differentiation and RNA interference Dynamics of HP1 transgene loci movement and silencing in living cells Simple procedure for automatic detection of unstable alleles in the myotonic dystrophy and Huntington's disease loci Distinct nuclear arrangement of active and inactive c-myc genes in control and differentiated colon carcinoma cells Differentiation-specific association of HP1alpha and HP1beta with chromocentres is correlated with clustering of TIF1beta at these sites Sledování změn genové exprese u pacientů s kolorektálním karcinomem pomocí cDNA microarrays technologie a jejich diagnostika pomocí transkripčních map Single-cell c-myc gene expression in relationship to nuclear domains. Chromatin changes induced by lamin A/C deficiency and the histone deacetylase inhibitor trichostatin A Topography of telomeres and structure of chromosome territories in human lymphocytes Applications of Image Registration in Human Genome Research Automated image analysis in fluorescence microscopy: From isolated cells to tissues and microarray images Automated confocal microscopy: The way of achieving both quality and quantity in 3D image cytometry Automated confocal microscopy: The way of achieving both quality and quantity in 3D image cytometry Automated acquisition and processing of multidimensional image data in confocal in vivo microscopy Colocalization of PML bodies and PML/RARalpha microspeckles with up- and down-regulated loci and changes of chromatin structure in APL leukemia cells Rapid Image Acquisition of Living Cells and its Limits Relationship of HP1 proteins to centromeric heterochromatin characterized by the presence of H3(K9) and absence of H3(K4) dimethylation Relationship of HP1 proteins centromeric heterochromatin characterized by the presence of H3(K9) and absence of H3(K4) dimethylation Topography of genetic loci in the nuclei of cells of colorectal carcinoma and adjacent tissue of colonic epithelium Topographic characterization of telomeres in healthy and various tumor cell lines determined in situ and in vivo Topographic characterization of telomeres in healthy and various tumor cell lines determined in situ and in vivo Towards a Fully Automated Tissue Cell Segmentation Method Analysis of biomedical image data acquired using optical microscopy Analysis of biomedical image data acquired using optical microscopy Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases
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