About: Comparative transcriptome maps: a new approach to the diagnosis of colorectal carcinoma patients using cDNA microarrays

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Comparative transcriptome maps: a new approach to the diagnosis of colorectal carcinoma patients using cDNA microarrays Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The progression of colorectal cancer involves accumulation of various genetic and epigenetic events that dramatically change gene expression. The aim of this study was to investigate a possible new approach to the diagnosis of colorectal carcinoma patients, based on their gene expression profiles. Human 19K cDNA microarrays were used to analyze the gene expression profiles of 18 colorectal carcinoma patients. Transcriptome maps (TM) were analyzed to detect chromosomal regions that could serve as potential diagnostic markers for colon cancer. A comparison of TMs showed chromosome regions with conserved changes of gene expression typical of colorectal cancer in general, and also patient-specific variable regions. We identified 195 genes with significantly altered expression in colon cancer. Functional analysis of the regulated genes distinguished three main categories: biological processes, cellular components, and molecular functions. The progression of colorectal cancer involves accumulation of various genetic and epigenetic events that dramatically change gene expression. The aim of this study was to investigate a possible new approach to the diagnosis of colorectal carcinoma patients, based on their gene expression profiles. Human 19K cDNA microarrays were used to analyze the gene expression profiles of 18 colorectal carcinoma patients. Transcriptome maps (TM) were analyzed to detect chromosomal regions that could serve as potential diagnostic markers for colon cancer. A comparison of TMs showed chromosome regions with conserved changes of gene expression typical of colorectal cancer in general, and also patient-specific variable regions. We identified 195 genes with significantly altered expression in colon cancer. Functional analysis of the regulated genes distinguished three main categories: biological processes, cellular components, and molecular functions. (en)
Title	Comparative transcriptome maps: a new approach to the diagnosis of colorectal carcinoma patients using cDNA microarrays Comparative transcriptome maps: a new approach to the diagnosis of colorectal carcinoma patients using cDNA microarrays (en)
skos:prefLabel	Comparative transcriptome maps: a new approach to the diagnosis of colorectal carcinoma patients using cDNA microarrays Comparative transcriptome maps: a new approach to the diagnosis of colorectal carcinoma patients using cDNA microarrays (en)
skos:notation	RIV/00216224:14330/06:00015299!RIV11-GA0-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1A8241), P(GA202/04/0907), P(IAA1065203), P(IAA5004306), Z(AV0Z50040507), Z(MSM0021622419)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Žaloudík, Jan Kozubek, Michal Svoboda, Zbyněk Kozubek, Stanislav Brázdilová, Silvie Luisa Krontorád Koutná, Irena Jansová, Eva Krontorád, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	469203
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/06:00015299
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	colorectal carcinoma; cDNA microarrays; transcriptome map; functional clustering; expression profiles (en)
http://linked.open.../riv/klicoveSlovo	cDNA microarrays expression profiles functional clustering transcriptome map colorectal carcinoma
http://linked.open...odStatuVydavatele	DK - Dánské království
http://linked.open...ontrolniKodProRIV	[900ABA19703E]
http://linked.open...i/riv/nazevZdroje	Clinical Genetics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	New possibilities of diagnostics of leukemia using DNA-microarrays High-resolution cytomery of living cells The use of combination of laser microbeam and cytometric techniques in the study of the structure and dynamics of human genome Human genome structure
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	69
http://linked.open...iv/tvurceVysledku	Jansová, Eva Kozubek, Stanislav Svoboda, Zbyněk Kozubek, Michal Brázdilová, Silvie Luisa Krontorád Koutná, Irena Žaloudík, Jan Krontorád, Petr
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Highly Parallel and Distributed Computing Systems
issn	0009-9163
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	14330
is http://linked.open...avai/riv/vysledek of	Comparative transcriptome maps: a new approach to the diagnosis of colorectal carcinoma patients using cDNA microarrays

Faceted Search & Find service v1.16.116 as of Feb 22 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of Feb 22 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 67 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software