About: New insights into gene positional clustering and its properties supported by large-scale analysis of various differentiation pathways

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About: New insights into gene positional clustering and its properties supported by large-scale analysis of various differentiation pathways Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	To understand how genes are distributed on chromosomes we bring new insights into gene positional clustering and its properties. We have made a large-scale analysis of three types of differentiation and we observed that genes that subsequently enter into different cell processes are positionally clustered on chromosomes. Genes from the clusters are transcribed subsequently with respect to time kinetics and also to position. This means that the genes related to a cellular process are clustered together, independent of the period of time during which they are active and important for the process. Our results also demonstrate not only that there are general regions of increased or decreased levels of gene expression, but also that, in fact, in some chromosome regions we can find clustering of genes related to specific cell processes. To understand how genes are distributed on chromosomes we bring new insights into gene positional clustering and its properties. We have made a large-scale analysis of three types of differentiation and we observed that genes that subsequently enter into different cell processes are positionally clustered on chromosomes. Genes from the clusters are transcribed subsequently with respect to time kinetics and also to position. This means that the genes related to a cellular process are clustered together, independent of the period of time during which they are active and important for the process. Our results also demonstrate not only that there are general regions of increased or decreased levels of gene expression, but also that, in fact, in some chromosome regions we can find clustering of genes related to specific cell processes. (en)
Title	New insights into gene positional clustering and its properties supported by large-scale analysis of various differentiation pathways New insights into gene positional clustering and its properties supported by large-scale analysis of various differentiation pathways (en)
skos:prefLabel	New insights into gene positional clustering and its properties supported by large-scale analysis of various differentiation pathways New insights into gene positional clustering and its properties supported by large-scale analysis of various differentiation pathways (en)
skos:notation	RIV/00216224:14330/07:00019031!RIV10-MZ0-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1A8241), P(GA204/06/0978), P(GP301/04/P136), P(IAA5004306), P(LC535), Z(AV0Z50040507), Z(MSM0021622419)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kozubek, Michal Svoboda, Zbyněk Bártová, Eva Kozubek, Stanislav Krontorád Koutná, Irena Krontorád, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	437148
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/07:00019031
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Gene clustering; Differentiation; Microarrays; HL-60; K-562 (en)
http://linked.open.../riv/klicoveSlovo	HL-60 Gene clustering K-562 Microarrays Differentiation
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[5E6246F8DA36]
http://linked.open...i/riv/nazevZdroje	Genomics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	New possibilities of diagnostics of leukemia using DNA-microarrays Chromosome dynamics and organization during the cell cycle in normal and pathologic conditions Postranslational modifications of histones after cell treatment by inhibitors of histone deacetylases and during induction of cell differentiation Early diagnostics of leukemia using DNA-microchip technology and by monitoring of epigenetic changes Human genome structure
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	89
http://linked.open...iv/tvurceVysledku	Bártová, Eva Kozubek, Stanislav Svoboda, Zbyněk Kozubek, Michal Krontorád Koutná, Irena Krontorád, Petr
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Highly Parallel and Distributed Computing Systems
issn	0888-7543
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14330
is http://linked.open...avai/riv/vysledek of	New insights into gene positional clustering and its properties supported by large-scale analysis of various differentiation pathways New insights into gene positional clustering and its properties supported by large-scale analysis of various differentiation pathways New insights into gene positional clustering and its properties supported by large-scale analysis of various differentiation pathways

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