About: Topography of genetic loci in the nuclei of cells of colorectal carcinoma and adjacent tissue of colonic epithelium

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About: Topography of genetic loci in the nuclei of cells of colorectal carcinoma and adjacent tissue of colonic epithelium Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	To determine the influence of increased gene expression and amplification in colorectal carcinoma on chromatin structure, the nuclear distances between pairs of bacterial artificial chromosome (BAC) clones with genomic separation from 800 to 29,000 kb were measured and compared between the tumor and parallel epithelial cells of six patients. The nuclear distances were measured between the loci in chromosomal bands 7p22.3-7p21.3; 7q35-7q36.3; 11p15.5-11p15.4; 20p13; 20p12.2; 20q11.21 and 20q12 where increased expression had been found in all types of colorectal carcinoma. The loci were visualized by three-dimensional fluorescence in situ hybridization using 22 BAC clones. Our results show that for short genomic separations, mean nuclear distance increases linearly with increased genomic separation. The results for some pairs of loci fell outside this linear slope, indicating the existence of different levels of chromatin folding. To determine the influence of increased gene expression and amplification in colorectal carcinoma on chromatin structure, the nuclear distances between pairs of bacterial artificial chromosome (BAC) clones with genomic separation from 800 to 29,000 kb were measured and compared between the tumor and parallel epithelial cells of six patients. The nuclear distances were measured between the loci in chromosomal bands 7p22.3-7p21.3; 7q35-7q36.3; 11p15.5-11p15.4; 20p13; 20p12.2; 20q11.21 and 20q12 where increased expression had been found in all types of colorectal carcinoma. The loci were visualized by three-dimensional fluorescence in situ hybridization using 22 BAC clones. Our results show that for short genomic separations, mean nuclear distance increases linearly with increased genomic separation. The results for some pairs of loci fell outside this linear slope, indicating the existence of different levels of chromatin folding. (en)
Title	Topography of genetic loci in the nuclei of cells of colorectal carcinoma and adjacent tissue of colonic epithelium Topography of genetic loci in the nuclei of cells of colorectal carcinoma and adjacent tissue of colonic epithelium (en)
skos:prefLabel	Topography of genetic loci in the nuclei of cells of colorectal carcinoma and adjacent tissue of colonic epithelium Topography of genetic loci in the nuclei of cells of colorectal carcinoma and adjacent tissue of colonic epithelium (en)
skos:notation	RIV/00216224:14330/04:00009648!RIV11-AV0-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA202/01/0197), P(GA202/02/0804), P(IAA1065203), P(IAA5004306), P(ME 565), P(NC6987), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Žaloudík, Jan Kozubek, Michal Vagunda, Václav Kozubek, Stanislav Falk, Martin Pavlovský, Zdeněk Lukášová, Emilie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	590471
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/04:00009648
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	chromatin structure; colorectal carcinoma (en)
http://linked.open.../riv/klicoveSlovo	chromatin structure colorectal carcinoma
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[4F5497D777D6]
http://linked.open...i/riv/nazevZdroje	Chromosoma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20565 Epigenetic control of gene expression in malignant diseases Ionising radiation as a tool in the investigations of the cell nuclear structure and in the development of new techniques for ecology and medicine Chronic myeloid leukemia radiation risk estimation based on BCR-ABL distances in hemotopoietic cells The use of combination of laser microbeam and cytometric techniques in the study of the structure and dynamics of human genome Human genome structure
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	112
http://linked.open...iv/tvurceVysledku	Kozubek, Stanislav Lukášová, Emilie Falk, Martin Kozubek, Michal Pavlovský, Zdeněk Žaloudík, Jan Vagunda, Václav
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0009-5915
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	14330

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