About: Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases

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About: Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The effects of the histone deacetylase inhibitors (HDACi) trichostatin A (TSA) and sodium butyrate (NaBt) were studied in A549, HT29 and FHC human cell lines. Global histone hyperacetylation, leading to decondensation of interphase chromatin, was characterized by an increase in H3(K9) and H3(K4) dimethylation and H3(K9) acetylation. The levels of all isoforms of heterochromatin protein, HP1, were reduced after HDAC inhibition. The observed changes in the protein levels were accompanied by changes in their interphase patterns. In control cells, H3(K9) acetylation and H3(K4) dimethylation were substantially reduced to a thin layer at the nuclear periphery, whereas TSA and NaBt caused the peripheral regions to become intensely acetylated at H3(K9) and dimethylated at H3(K4). The dispersed pattern of H3(K9) dimethylation was stable even at the nuclear periphery of HDACi-treated cells. The effects of the histone deacetylase inhibitors (HDACi) trichostatin A (TSA) and sodium butyrate (NaBt) were studied in A549, HT29 and FHC human cell lines. Global histone hyperacetylation, leading to decondensation of interphase chromatin, was characterized by an increase in H3(K9) and H3(K4) dimethylation and H3(K9) acetylation. The levels of all isoforms of heterochromatin protein, HP1, were reduced after HDAC inhibition. The observed changes in the protein levels were accompanied by changes in their interphase patterns. In control cells, H3(K9) acetylation and H3(K4) dimethylation were substantially reduced to a thin layer at the nuclear periphery, whereas TSA and NaBt caused the peripheral regions to become intensely acetylated at H3(K9) and dimethylated at H3(K4). The dispersed pattern of H3(K9) dimethylation was stable even at the nuclear periphery of HDACi-treated cells. (en)
Title	Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases (en)
skos:prefLabel	Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases (en)
skos:notation	RIV/00216224:14330/05:00012958!RIV11-GA0-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1A8241), P(1QS500040508), P(GA202/04/0907), P(GP202/03/D033), P(IAA5004306), P(LC535), Z(AV0Z50040507)
http://linked.open...iv/cisloPeriodika	21
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kozubek, Michal Bártová, Eva Kozubek, Stanislav Hofmanová, Jiřina Harničarová Horáková, Andrea Skalníková, Magdalena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	533446
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/05:00012958
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	histone dimethylation; histone acetylation; HP1 proteins; HDAC inhibitors; nuclear periphery (en)
http://linked.open.../riv/klicoveSlovo	HDAC inhibitors histone acetylation HP1 proteins histone dimethylation nuclear periphery
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E5B6D6569CC1]
http://linked.open...i/riv/nazevZdroje	Journal of Cell Science
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	New possibilities of diagnostics of leukemia using DNA-microarrays Methylation of histone H3 as a prognostic marker of chronic myeloid leukemia remission Chromosome dynamics and organization during the cell cycle in normal and pathologic conditions High-resolution cytomery of living cells The efect of methylation and acetylation on chromatin structure Human genome structure
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	118
http://linked.open...iv/tvurceVysledku	Bártová, Eva Hofmanová, Jiřina Kozubek, Stanislav Kozubek, Michal Pacherník, J. Harničarová, Andrea Skalníková, Magdalena Kovaříková, M. Kovařík, A.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems
issn	0021-9533
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	14330

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