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| Description
| - Dietary supplements containing natural compounds are increasingly popular. Dietary supplements became an alternative to classical medication and they are widely believed to be safe and without any adverse effects or interactions with drugs. However, some natural compounds present in high concentrations in dietary supplements are known to cause serious toxicities. Moreover, the toxicological profiles of certain supplements have not been systematically examined. The aim of the project is to evaluate interactions of selected natural constituents with drug-metabolizing enzymes, transporters and nuclear receptors to predict possible interactions with clinically relevant drugs and further characterize biological properties of the natural compounds and their metabolites. The influence of genetic predisposition on kinetics and adverse effects of these compounds will also be followed. Finally, we will provide recommendations for general population as well as for individuals with polymorphic biotransformation and predict idiosyncratic toxicity of the studied natural compounds. (en)
- Doplňky stravy obsahující farmakologicky aktivní látky přírodní povahy jsou čím dál tím více rozšířené a v povědomí laické i odborné veřejnosti zůstávají jako alternativa klasické farmakoterapie bez nežádoucích nebo vedlejších účinků. Některé doplňky stravy však obsahují vysoké koncentrace aktivních látek, látek potenciálně toxických nebo látek s nedostatečně definovanými účinky. Cílem tohoto projektu je studovat interakce vybraných skupin rostlinných látek, například polyfenolické povahy, obsažených v doplňcích stravy s nejdůležitějšími biotransformačními enzymy, transportéry a nukleárními receptory s ohledem na jejich potenciální klinicky významné interakce s léčivy. Druhým cílem je charakterizovat farmakologické a toxikologické vlastnosti vybraných látek přírodního původu a jejich metabolitů a studovat vliv genetické predispozice na kinetiku a nežádoucí účinky těchto látek. Předpokládaným výsledkem tohoto projektu je rozšíření znalostí o některých skupinách látek přírodního původu, eliminace jejich možných interakcí s léčivy a racionalizace užívání doplňků stravy.
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| Title
| - Centre of drug-dietary supplements interactions and nutrigenetics (en)
- Centrum interakcí potravních doplňků s léčivy a nutrigenetiky
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - dietary supplements biotransformation pharmacokinetics nutrigenetics (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...tniCyklusProjektu
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| is http://linked.open...vavai/riv/projekt
of | - Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo
- Effect of dihydromyricetin on benzo[a]pyrene activation in rats
- The effect of anthocyans on the expression of selected phase II xenobiotic-metabolizing enzymes in primary cultures of human hepatocytes.
- Effect of selected catechins on doxorubicin antiproliferative efficacy and hepatotoxicity in vitro
- Essential oil from Myrica rubra leaves inhibits cancer cell proliferation and induces apoptosis in several human intestinal lines
- Effect of standardized cranberry extract on the activity and expression of selected biotransformation enzymes in rat liver and intestine
- Enzymes Oxidizing the Azo Dye 1-Phenylazo-2-Naphthol (Sudan I) and their Contribution to its Genotoxicity and Carcinogenicity
- Effects of Anthocyanidins and Anthocyanins on the Expression and Catalytic Activities of CYP2A6, CYP2B6, CYP2C9, and CYP3A4 in Primary Human Hepatocytes and Human Liver Microsomes
- Biosafety and antioxidant effects of a beverage containing silymarin and arginine. A pilot, human intervention cross-over trial
- Construction and characterization of peroxisome proliferator-activated receptor-gamma co-activator 1 alpha (PGC-1 alpha over-expressing cell line derived from human hepatocyte carcinoma HepG2 cells)
- Dehydroepiandrosterone post-transcriptionally modifies CYP1A2 induction involving androgen receptor
- Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines
- Effects of glucocorticoids on cytochrome P450 1A1 (CYP1A1) expression in isolated human placental trophoblast
- Inhibitory effect of anthocyanidins on hepatic glutathione S-transferase, UDP-glucuronosyltransferase and carbonyl reductase activities in rat and human
- Interaction of Anthocyanins with Drug-metabolizing and Antioxidant Enzymes
- Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T
- Optimized Protocol of Chicken Antibody (IgY) Purification Providing Electrophoretically Homogenous Preparations
- A paradigm for AhR-mediated alleviation of type 1 diabetes mellitus pathology by isoquinoline alkaloid berberine
- Iron reduction potentiates hydroxyl radical formation only in flavonols
- Age-Related Changes in Hepatic Activity and Expression of Detoxification Enzymes in Male Rats
- Isoquercitrin: Pharmacology, toxicology, and metabolism
- Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2
- Dexamethasone accelerates degradation of aryl hydrocarbon receptor (AHR) and suppresses CYP1A1 induction in placental JEG-3 cell line
- The expression profile of ATP-binding cassette transporter genes in breast carcinoma
- Induced Expression of Cytochrome P450 1A and NAD(P)H:Quinone Oxidoreductase Determined at mRNA, Protein, and Enzyme Activity Levels in Rats Exposed to the Carcinogenic Azo Dye 1-Phenylazo-2-naphthol (Sudan I)
- Influence of gold(I) complexes involving adenine derivatives on major drug-drug interaction pathway
- Effects of flavored mineral waters on AhR-CYP1A1 signaling pathway in primary human hepatocytes and in human hepatic and intestinal cancer cells
- Evaluation of in vitro cytotoxicity of one-dimensional chain [Fe(salen)(L)]n complexes against human cancer cell lines
- Electrochemical Sensing of Total Antioxidant Capacity and Polyphenol Content in Wine Samples Using Amperometry Online-Coupled with Microdialysis
- The role of residues T248, Y249 and T422 in the function of human pregnane X receptor
- The relationship between DNA adduct formation by benzo[a]pyrene and expression of its activation enzyme cytochrome P450 1A1 in rat
- Construction and characterization of a reporter gene cell line for assessment of human glucocorticoid receptor activation
- Drug-induced cholestatic liver injury
- Drug-Metabolizing Enzymes - An Overview
- Formation, Persistence, and Identification of DNA Adducts Formed by the Carcinogenic Environmental Pollutant o-Anisidine in Rats
- Flavonoids
- In vitro platelet antiaggregatory properties of 4-methylcoumarins
- Inhibition and induction of glutathione S-transferases by flavonoids: possible pharmacological and toxicological consequences
- Naturally occurring flavonoids as inhibitors of purified cytosolic glutathione S-transferase
- Modulatory Effects of Quercetin and Rutin on the Activity, Expression and Inducibility of CYP1A1 in Intestinal HCT-8 Cells
- Metabolic Profiling of Phenolic Acids and Oxidative Stress Markers after Consumption of Lonicera caerulea L. Fruit
- Chemo-enzymatic synthesis of silybin and 2,3-dehydrosilybin dimers
- Oral administration of quercetin is unable to protect against isoproterenol cardiotoxicity
- Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier
- Post-translational and Post-transcriptional Modifications of Pregnane X Receptor (PXR) in Regulation of the Cytochrome P450 Superfamily
- Reference genes for real-time PCR quantification of messenger RNAs and microRNAs in mouse model of obesity
- Resveratrol as an Inhibitor of Pregnane X Receptor (PXR): Another Lesson in PXR Antagonism
- Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4alpha upregulation in primary human hepatocytes
- Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4alfa upregulation in primary human hepatocytes
- Keratin Cross-reactivity in Electro-transfer (Western blot): How to Suppress It
- Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells
- Antioxidant, Pro-Oxidant and Other Biological Activities of Sesquiterpenes
- Anthocyanidins pelargonidin and cyanidin reduce genotoxic stress in mice - Possible involvement of aryl hydrocarbon receptor in the process
- Non-coding polymorphisms in nucleotide binding domain 1 in ABCC1 gene associate with transcript level and survival of patients with breast cancer
- Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction
- Pressure effects reveal that changes in the redox states of the heme iron complexes in the sensor domains of two heme-based oxygen sensor proteins, Ec DOS and YddV, have profound effects on their flexibility
- Administration of a Probiotic Can Change Drug Pharmacokinetics: Effect of E. coli Nissle 1917 on Amidarone Absorption in Rats
- Importance of ABCC1 for cancer therapy and prognosis
- In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb.
- In vitro evaluation of copper-chelating properties of flavonoids
- Valproate activates ERK signaling pathway in primary human hepatocytes
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| is http://linked.open...vavai/cep/projekt
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