About: Isoquercitrin: Pharmacology, toxicology, and metabolism

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The flavonoid isoquercitrin (quercetin-3-O-beta-D-glucopyranoside) is commonly found in medicinal herbs, fruits, vegetables and plant-derived foods and beverages. This article reviews the occurrence, preparation, bioavailability, pharmacokinetics, toxicology and biological activity of isoquercitrin and %22enzymatically modified (alpha-glucosylated) isoquercitrin%22 (EMIQ). Pure isoquercitrin can now be obtained on a large scale by enzymatic rutin hydrolysis with alpha-L-rhamnosidase. Isoquercitrin has higher bioavailability than quercetin and displays a number of chemoprotective effects both in vitro and in vivo, against oxidative stress, cancer, cardiovascular disorders, diabetes and allergic reactions. Although small amounts of intact isoquercitrin can be found in plasma and tissues after oral application, it is extensively metabolized in the intestine and the liver The flavonoid isoquercitrin (quercetin-3-O-beta-D-glucopyranoside) is commonly found in medicinal herbs, fruits, vegetables and plant-derived foods and beverages. This article reviews the occurrence, preparation, bioavailability, pharmacokinetics, toxicology and biological activity of isoquercitrin and %22enzymatically modified (alpha-glucosylated) isoquercitrin%22 (EMIQ). Pure isoquercitrin can now be obtained on a large scale by enzymatic rutin hydrolysis with alpha-L-rhamnosidase. Isoquercitrin has higher bioavailability than quercetin and displays a number of chemoprotective effects both in vitro and in vivo, against oxidative stress, cancer, cardiovascular disorders, diabetes and allergic reactions. Although small amounts of intact isoquercitrin can be found in plasma and tissues after oral application, it is extensively metabolized in the intestine and the liver (en)
Title	Isoquercitrin: Pharmacology, toxicology, and metabolism Isoquercitrin: Pharmacology, toxicology, and metabolism (en)
skos:prefLabel	Isoquercitrin: Pharmacology, toxicology, and metabolism Isoquercitrin: Pharmacology, toxicology, and metabolism (en)
skos:notation	RIV/61388971:_____/14:00433017!RIV15-GA0-61388971
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(7E11011), P(GAP301/11/0767), P(GBP303/12/G163), P(LD13041)
http://linked.open...iv/cisloPeriodika	JUN 2014
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Valentová, Kateřina Křen, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	22968
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/14:00433017
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Quercetin-3-glucoside; Quercetin-3-O-beta-D-glucopyranoside; Enzymatically modified isoquercitrin (en)
http://linked.open.../riv/klicoveSlovo	Enzymatically modified isoquercitrin Quercetin-3-O-beta-D-glucopyranoside Quercetin-3-glucoside
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[8D63081E178F]
http://linked.open...i/riv/nazevZdroje	Food and Chemical Toxicology
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre of drug-dietary supplements interactions and nutrigenetics Supramolecular antioxidants protecting proteins against oxidative damage Modulation of intestinal inflammation and nitric oxide production by quercetin and its conjugates Novel Biocatalysts for the Production of Glycosides
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	68
http://linked.open...iv/tvurceVysledku	Křen, Vladimír Ulrichová, J. Valentová, Kateřina Vrba, J. Bancířová, M.
http://linked.open...ain/vavai/riv/wos	000337653000029
issn	0278-6915
number of pages	16 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.fct.2014.03.018

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