About: Novel Biocatalysts for the Production of Glycosides

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=7E11011
Description	This project aims to develop novel biocatalysts for the production of glycosides (NOVOSIDES). Glycosylated compounds have a wide range of applications, but very few enzymes are able to glycosylate small organic molecules cost-efficiently at the industrial scale. Therefore, glycosylation reactions catalysed by transglycosidases, glycoside phosphorylases and glycoside hydrolases will be explored in more detail. These enzymes catalyze the transfer a glycosyl group from a cheap and readily available donor substrate to a variety of acceptors. To exploit their full potential, the enzymes’ specificity and stability against high temperatures and the presence of organic co-solvents will be optimised by means of directed evolution. (en) This project aims to develop novel biocatalysts for the production of glycosides (NOVOSIDES). Glycosylated compounds have a wide range of applications, but very few enzymes are able to glycosylate small organic molecules cost-efficiently at the industrial scale. Therefore, glycosylation reactions catalysed by transglycosidases, glycoside phosphorylases and glycoside hydrolases will be explored in more detail. These enzymes catalyze the transfer a glycosyl group from a cheap and readily available donor substrate to a variety of acceptors. To exploit their full potential, the enzymes’ specificity and stability against high temperatures and the presence of organic co-solvents will be optimised by means of directed evolution.
Title	Novel Biocatalysts for the Production of Glycosides (en) Novel Biocatalysts for the Production of Glycosides
skos:notation	7E11011
http://linked.open...avai/cep/aktivita	Subvention of the projects of the Seventh Framework Programme of the European Community for research, technological development including demonstration activities (FP7) according to the Czech law 171/2007 Sb.
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/7E11011/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/7E11011/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2015-02-16 (xsd:date)
http://linked.open...i/cep/druhSouteze	RP - Spolufinancování programu ES
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	100525992
http://linked.open...ai/cep/hlavniObor	CE - Biochemie
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	Glycoside; transglycosidase; phosphorylase; directed evolution; metagenome; fluorescence probes (en)
http://linked.open...ep/partnetrHlavni	Mikrobiologický ústav AV ČR, v.v.i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	13 (xsd:int)
http://linked.open...enychVysledkuVRIV	13 (xsd:int)
http://linked.open...lneniVMinulemRoce	2013-03-27 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/MSMT-1839%2F2013-310
http://linked.open...iciPoslednihoRoku	2014
http://linked.open...atUdajeProjZameru	2014
http://linked.open...usZobrazovaneFaze	DRRVK
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2014-11-30 (xsd:date)
http://linked.open.../cep/vedlejsiObor	EI - Biotechnologie a bionika EE - Mikrobiologie, virologie
http://linked.open...ep/zahajeniReseni	2011-01-01 (xsd:date)
http://linked.open...tniCyklusProjektu	ZBBK
http://linked.open...n/vavai/cep/vyzva	http://linked.opendata.cz/resource/domain/vavai/cep/vyzva/FP7-KBBE-2010-4
http://linked.open.../cep/klicoveSlovo	Glycoside directed evolution metagenome phosphorylase transglycosidase
is http://linked.open...vavai/riv/projekt of	Crystallization and preliminary X-ray crystallographic analysis of recombinant -mannosidase from Aspergillus niger Ionic liquids as cosolvents for glycosylation by sucrose phosphorylase: balancing acceptor solubility and enzyme stability Isoquercitrin: Pharmacology, toxicology, and metabolism Inhibition of microbial β-N-acetylhexosaminidases by 4-deoxy- and galacto-analogues of NAG-thiazoline Carbohydrate synthesis and biosynthesis technologies for cracking of the glycan code: Recent advances Chemoenzymatic synthesis of alpha-L-rhamnosides using recombinant alpha-L-rhamnosidase from Aspergillus terreus Production of Aspergillus niger beta-mannosidase in Pichia pastoris Sequencing, cloning and high-yield expression of a fungal beta-N-acetylhexosaminidase in Pichia pastoris Facile synthesis of nitrophenyl 2-acetamido-2-deoxy-alpha-D-mannopyranosides from ManNAc-oxazoline Biphasic Catalysis with Disaccharide Phosphorylases: Chemoenzymatic Synthesis of alpha-D-Glucosides Using Sucrose Phosphorylase Preparatory production of quercetin-3-beta-D-glucopyranoside using alkali-tolerant thermostable alpha-L-rhamnosidase from Aspergillus terreus Expression, characterization and homology modeling of a novel eukaryotic GH84 beta-N-acetylglucosaminidase from Penicillium chrysogenum Protein engineering study of beta-mannosidase to set up a potential chemically efficient biocatalyst
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/7E11011/2011/ico%3A61388971 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/7E11011/2012/ico%3A61388971 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/7E11011/2013/ico%3A61388971 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/7E11011/2014/ico%3A61388971

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