About: Carbohydrate synthesis and biosynthesis technologies for cracking of the glycan code: Recent advances

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The glycan code of glycoproteins can be conceptually defined at molecular level by the sequence of well characterized glycans attached to evolutionarily predetermined amino acids along the polypeptide chain. Functional consequences of protein glycosylation are numerous, and include a hierarchy of properties from general physicochemical characteristics such as solubility, stability and protection of the polypeptide from the environment up to specific glycan interactions. Definition of the glycan code for glycoproteins has been so far hampered by the lack of chemically defined glycoprotein glycoforms that proved to be extremely difficult to purify from natural sources, and the total chemical synthesis of which has been hitherto possible only for very small molecular species The glycan code of glycoproteins can be conceptually defined at molecular level by the sequence of well characterized glycans attached to evolutionarily predetermined amino acids along the polypeptide chain. Functional consequences of protein glycosylation are numerous, and include a hierarchy of properties from general physicochemical characteristics such as solubility, stability and protection of the polypeptide from the environment up to specific glycan interactions. Definition of the glycan code for glycoproteins has been so far hampered by the lack of chemically defined glycoprotein glycoforms that proved to be extremely difficult to purify from natural sources, and the total chemical synthesis of which has been hitherto possible only for very small molecular species (en)
Title	Carbohydrate synthesis and biosynthesis technologies for cracking of the glycan code: Recent advances Carbohydrate synthesis and biosynthesis technologies for cracking of the glycan code: Recent advances (en)
skos:prefLabel	Carbohydrate synthesis and biosynthesis technologies for cracking of the glycan code: Recent advances Carbohydrate synthesis and biosynthesis technologies for cracking of the glycan code: Recent advances (en)
skos:notation	RIV/61388971:_____/13:00395423!RIV14-MSM-61388971
http://linked.open...avai/predkladatel	Mikrobiologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(7E11011), P(GA303/09/0477), P(GAP207/10/0321), P(GD305/09/H008), P(LD13041)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Weignerová, Lenka Bezouška, Karel Novák, Petr Bojarová, Pavla Vaněk, Ondřej Mrázek, Hynek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	64255
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/13:00395423
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cellular factories; Complex carbohydrates; Glycodrugs (en)
http://linked.open.../riv/klicoveSlovo	Cellular factories Complex carbohydrates Glycodrugs
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[CCF905E24AF2]
http://linked.open...i/riv/nazevZdroje	Biotechnology Advances
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Preparation, biotransformation, and optimalization of compounds with antitumor and antimicrobial effects Supramolecular antioxidants protecting proteins against oxidative damage Novel Biocatalysts for the Production of Glycosides Glycomic and proteomic analysis of the molecular mechanisms of elimination of clinically relevant tumors by killer cells of the immune system The ways to N-acetyl-mannosamine structures via mannoside metabolizing enzymes
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Bezouška, Karel Bojarová, Pavla Novák, Petr Vaněk, Ondřej Weignerová, Lenka Mrázek, Hynek
http://linked.open...ain/vavai/riv/wos	000315761200003
issn	0734-9750
number of pages	21 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.biotechadv.2012.03.008

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