About: In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb.

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About: In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.pjps.pk/wp-content/uploads/pdfs/27/1/Paper-15.pdf
Description	The aim of this study was to evaluate in vitro anti-proliferative (tested on MCF-7, MDA-MB-231, and MCF-10A cell lines) and anti-inflammatory (evaluated as inhibition of prostaglandin E-2 synthesis catalyzed by cyclooxygenase-2) effect of various extracts from Vaccinium bracteatum leaves and fruits. The highest anti-proliferative effect possessed leaf dichloromethane extract with IC50 values ranging from 93 to 198 mu g/mL. In the case of cyclooxygenase-2 inhibition, n-hexane, dichloromethane, and ethanol fruit extracts showed the best activity with IC50 values = 2.0, 5.4, and 12.7 mu g/mL, respectively. These results indicate that V bracteatum leaves and fruits could be useful source of anti-cancer and anti-inflammatory compounds. The aim of this study was to evaluate in vitro anti-proliferative (tested on MCF-7, MDA-MB-231, and MCF-10A cell lines) and anti-inflammatory (evaluated as inhibition of prostaglandin E-2 synthesis catalyzed by cyclooxygenase-2) effect of various extracts from Vaccinium bracteatum leaves and fruits. The highest anti-proliferative effect possessed leaf dichloromethane extract with IC50 values ranging from 93 to 198 mu g/mL. In the case of cyclooxygenase-2 inhibition, n-hexane, dichloromethane, and ethanol fruit extracts showed the best activity with IC50 values = 2.0, 5.4, and 12.7 mu g/mL, respectively. These results indicate that V bracteatum leaves and fruits could be useful source of anti-cancer and anti-inflammatory compounds. (en)
Title	In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb. In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb. (en)
skos:prefLabel	In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb. In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb. (en)
skos:notation	RIV/00216208:11160/14:10281579!RIV15-MSM-11160___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GBP303/12/G163), P(ME08070), S
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Boušová, Iva Skálová, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	21069
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/14:10281579
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	xCELLigence system; Vaccinium bracteatum; cyclooxygenase; breast cancer; anti-inflammatory activity; anti-proliferative activity (en)
http://linked.open.../riv/klicoveSlovo	breast cancer anti-proliferative activity cyclooxygenase anti-inflammatory activity Vaccinium bracteatum xCELLigence system
http://linked.open...odStatuVydavatele	PK - Pákistánská islámská republika
http://linked.open...ontrolniKodProRIV	[EF0001807B1A]
http://linked.open...i/riv/nazevZdroje	Pakistan Journal of Pharmaceutical Sciences
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre of drug-dietary supplements interactions and nutrigenetics Biotechnological production of Vaccinium bracteatum and evaluation of its biological activity
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Boušová, Iva Vaněk, Tomáš Landa, Přemysl Skálová, Lenka Langhansová, Lenka Kutil, Zsofia Lou, Ji-Dong
http://linked.open...ain/vavai/riv/wos	000346327000015
issn	1011-601X
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	11160

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