About: Research and development in the sphere of oncology

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rdf:type	http://linked.opendata.cz/resource/domain/vavai/Aktivita
Title	Research and development in the sphere of oncology (en) Výzkum a vývoj v oblasti Onkologie (cs)
skos:notation	NC
http://linked.open...ai/cea/pgm/XD_PGM	240
http://linked.open...a/pgm/cilAktivity	Reduction of incidence of tumors and oncological morbidity and mortality, reduction of oncogenic burden of an individual, as well as of the population, individual approach to the treatment of malign tumours (en) Snížení incidence nádorů a onkologické morbidity a mortality, snížení onkogenní zátěže jedince i populace, ndividualizace léčby zhoubných nádorů (cs)
http://linked.open...a/pgm/rokUkonceni	2005
http://linked.open...a/pgm/rokZahajeni	1998
http://linked.open...a/pgm/typAktivity	P - Program
http://linked.open...ai/cea/pgm/resort	Ministry of Health
is http://linked.open...avai/cep/aktivita of	Detection of RET proto-oncogene mutations in families with medullary thyroid cancer, syndrome MEN 2 - predictive molecular genetic analysis Quality assurance of rediotherapy - treatment planning systems. How the study spatial order of specific genetic loci in nuclei of healthy and malignant tissues can contribute to the diagnostics and treatment of solid tumors. The significance of mitochondriál DNA mutations in the pathogenesis of refractory anaemia with ring sideroblasts Changes of lipid metabolism and its mediator-related effects in patients with colorectal carcinoma - perspective impact in nutritional support. Modulation of Bcl-2 expression in prostate cancer:Possible tool for hormone refractory tumours diagnosis and optimalisation of their therapy. The assessment of apoptosis and proliferative indices of plasma cells in patiens with multiple myeloma. Determination of functional status of tumor suppressor p53 in acute myeloid leukemia by using of method FASAY. The role of homologues, p73, p63 and KET proteins, in cell cycle, malignant transformation of the cell and apoptosis. Significance of human papillomavirus in aetiology and prognosis of oropharyngeal and oral cancer Clinical study of boron neutron capture therapy. Phase I. Ovarian germ cell tumours in childhood and adolescence. Retrospektive clinical-pathologic study. Treatment strategy in children with high-risk forms of leukemia using hematopoietic stem cell transplantation Experimental photodynamic therapy of tumore with employment of liposomal forms of novel photosenzitizers The lung carcinoma metastatic potential estimation, its prognostic and clinical aspects Monitoring of specific merkers of bone metabolism - corelation to bone involvement in multiple myeloma Modulation of expression and activity of some genes regulating cell cycle and apoptosis by steroids and their receptors in the glial tumours Clinical and pothogenetic aspects of telomerase activity in colorectal and breast cancer with respect to their sporadic versus hereditary occurence Use of monoclonal immunoglobulin for preparation of antitumor vaccine in patients with multiple myeloma Analysis of PTEN gene interactions in prostate cancer cell lines Transcription factor microphthalmia as a regulator of cell differentiation in malignant melanocytes Immunotherapy of chronic myeloid leukemia: therapeutic vaccines in a mouse model and preparation of a clinical study Epigenetic control of gene expression in malignant diseases Telomerase activity as a novel prognostic factor in multiple myeloma Plasma homocysteine and functional activation of p53 as putative markers of effect of high-dose methotrexate in lymphoblastic malignancies in children Analysis of functional alterations of mutant forms of p53 protein in human cancers. Health check-up database utilization for epidemiological studies The research of interactions between metabolism of fluorinated pyrimidines and ionizing radiation, influence on prediction of chemoradiotherapy effects Importance of chromosomal aberations detected by CGH in neuroblastoma and Ewing´s sarcoma The use of three-dimensional gel dosimetry in radiation oncology for verification of treatment techniques Comparison of expression of VEGF, TGF, IL6, IL10 and bounding proteins in oropharyngeal cancers and their metastasis with those in chronic tonsillitis Angiogenesis, angiogenic cytokines and indices of plasma cell kinetics in multiple myeloma: clinical and prognostic significance Study of predisposing genetic factors in breast cancer HPV and Anogenital Cancer The role of positron emission tomography (PET) with fluorodeoxyglucose (18FDG) in the management of children and adolescents with malignant lymphomas. Towards quantitative evaluation of lymphoscintigraphy in diagnostics and treatment of lymphedema of upper limbs Gene Therapy of Cancer - Optimization of Therapeutic Protocols Gene Therapy of Cancer - Optimization of Therapeutic Protocols Intraoperative Radioimmunodetection of Colorectal Cancer. Influence of the boar seminal immunosupressor on cells of human immune system The detection of residual disease after high-dose therapy in multiple myeloma Detection and monitoring of certain chromosomal abnormalities in children suffering from acuta myeloid leukemia Relationship of capillary neovascularization in breast carcinoma to its metastatic potency and prognosis The intensive cyclic chemotherapy supported with whole blood rich in PBPC in the treatment of breast and lung cancer Quantification of the influence of biophysical characteristics on 131I therapy of thyroid cancer Diagnostic and prognostic markers in the oncology Correlation of proliferative and apoptopic dynamics in hematopathology, related to clinical and morphological parameters in bone marrow biopsies. Prognostic significance of apoptopic rate in relation to altered content of DNA in glial tumours of brain Verification of DNA Profile as a Prognostic Factor and Monitoring Chemotherapy-Induced Clonal Evolution of Squamous Cell Carcinomas in Waldayer's Circuit by Flo Randomized Multicentre Prospective Study of Induction of Patients with AML, of Older Age /56-75 years/ Followed by Stratified Consolitation Treatment. Induction of graft versus leukemia effect in patients with chronic myeloid leukemia Elements Predicting Outcome in the Treatment of Oropharyngeal Carcinoma Tumour markers in diagnosing, monitoring and prognosing pancreatic cancer Folow up factors of prognosis and progression of tumor diseaese by patients with neoplasms of lung, colorectum, stomach and ovary. The p53 response to DNA damage and disruption of its regulation in cancer cells. Liposomal photodynamic therapy of tumors Nucleoli in blasts of acute leukemias and preleukemic states /myelodyspastic syndroma including transformation to leukemia/ in patients untreated and treated wi Study of new prognostic factors in malignant lymphomas and treatment innovation of their prognostically unfavourable forms. %22Immunohistochemical detection of bone marrow micrometastases in breast and prostate cancer. Retrospective and prospective study%22. Boron neutron capture therapy of brain tumors - clinical utilization Long term molecular follow up of chimerism in bone marrow transplanted patients K-ras oncogene mutations examination in malignant and non-malignant diseases of pancreas and hepatho-billiar tract Study of apoptosis in human nonsmall cell lung cancer molecular cytogenetic diagnosis of chronic lymphocytic leukemias /CLL/. Receptor-mediated drug targeting info human colorectal cancer Detection and ex vivo elimination of residual tumor cells of autologous stem cell sources with protection of stem cells by amifostine in children Dominant negative mutants of nuclear hormone receptors The prognostic factors of proliferation and angiogenesis in thyroid tumours Interaction of tumor supressor protein p53 with damaged DNA and with DNA lesions induced by anti-cancer drugs Thyroid oncology The role of transcriptional coactivators in malignant transformation and in the dedifferentiation of tumours cells MECHANISMUS OF Bcl-2 ACTION Combined therapy of minimal residual disease using IL-2 and GM-CSF as recombinant cytokines or genetically modified vaccines Genetic Analysis of Candidate Genes in Acute Myeloid Leukemias and Myelodyplastic Syndromes Expression of cell cycle regulators in acute myeloid leukemia and myelodysplastic syndrome Mutational analysis of BRCA1 and BRCA2 genes in hereditary forms of breast and ovarian cancer. Clinical application in the South Moravian region. DOES ANY SPECIFIC IMBALANCE IN CYTOKINES OF T HELPER CELL ORIGINE ASSOCIATE WITH CANCER AND ITS RESPONSE TO CYTOKINE-BASED THERAPY? The use of cultured breast cancer cells for the development of the individualized chemosensitivity/chemoresistance assay in vitro. Drug resistance gene transfer into hematopoietic cells for protection against toxic and mutagenic effects of chemoterapy. USE OF TELEPHONE LINE PROVIDING PSYCHOTHERAPY IN CANCER PATIENS. Mutation analysis of the BRCA1 and BRCA2 genes:early diagnostics of hereditary breast and ovarian cancer. Molecular mechanism of cancer therapy based on photoactivation of induced endogenous protoporphyrin IX (ALA-PDT). Gene immunotherapy of tumours with different expression of MHC-I. Molecular markers of chronic myeloid leukemia progression to blast crisis. Changes of telomere length and telomere activity in hematological neoplasias and their clinical implications in diagnosis,prognosis, and treatment. Nucleoli in blood cells of patients from suffering from leukemias and preleukemias (myelodysplastic syndromes) with a special regard to micronucleoli. Study of the regulation of ribosomal RNA synthesis in normal and malignant blood cells. HPV and progression of borderline cervical cytological findings (ACSUS/AGUS). The expression of PAX5 gene in transitional cell bladder cancer.Its prognostic role and comparing with p53 pathology and chromosome 9 microsalellite instability.

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