About: Gene immunotherapy of tumours with different expression of MHC-I.

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About: Gene immunotherapy of tumours with different expression of MHC-I. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=NC5900
Description	Induction of immunity against tumours cells producing HPV16 E7 oncoprotein and differing in the degree of MHC-I expression.Combination of DNA immunization and immunization with transduced tumour cells. Enhancement of immune responses by heat-shock proteins. (en) Vyvolání imunity proti nádorovým buňkám produkujícím onkoprotein E7 HPV16 a lišícím se stupněm exprese MHC-I.Kombinace imunizace pomocí DNA a transdukovaných nádorových buněk.Využití proteinů teplotního šoku k zesílení imunitních odpovědí.
Title	Gene immunotherapy of tumours with different expression of MHC-I. (en) Genová imunoterapie nádorů s rozdílnou produkcí MHC-I.
skos:notation	NC5900
http://linked.open...avai/cep/aktivita	Research and development in the sphere of oncology
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/NC5900/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/NC5900/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2003-07-31 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	1136439
http://linked.open...ai/cep/hlavniObor	FD - Onkologie a hematologie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open.../cep/klicovaSlova	gene immunotherapy;HPV;DNA immunization;suicide genes;fusion genes;MHC-I expression;Hsp 70 (en)
http://linked.open...ep/partnetrHlavni	Ústav hematologie a krevní transfúze
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	31 (xsd:int)
http://linked.open...enychVysledkuVRIV	31 (xsd:int)
http://linked.open...iciPoslednihoRoku	2003
http://linked.open...atUdajeProjZameru	2003
http://linked.open.../vavai/cep/soutez	SMZ0NC2000
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open.../cep/vedlejsiObor	FP - Ostatní lékařské obory
http://linked.open...jektu+dodavatelem	Mezi nejvýznamnější přínos projektu lze považovat rozsáhlé spektrum výsledků studia protinádorového účinku DNA a buněčných vakcín v originálních modelech myších buněk, transformovaných onkogeny E6 a E7 lidského papillomaviru typu 16. (cs)
http://linked.open...tniCyklusProjektu	ZBKU
http://linked.open.../cep/klicoveSlovo	HPV DNA immunization MHC-I expression fusion genes gene immunotherapy suicide genes
is http://linked.open...vavai/riv/projekt of	Combined immunization with fusion genes of mutated E7 gene of human papillomavirus type 16 did not enhance antitumor effect. Gene immunotherapy of tumors with different expression of MHC class I. Local cytokine treatment of HPV16-associated tumours results in reduction of their lung metastases. Local therapy of HPV16-induced carcinoma with IL-2 gene modified and dendritic cell (DC)-based tumour vaccines. Local cytokine treatment of HPV16-associated tumours results in inhibition of their lung metastases. Delivery of recombinant adeno-associated virus by jet injection. Vaccination with HPV16 E7 antigen fused with glucuronidase. Tumour-inhibitory and antimetastatic effects of IL-2 in mice carrying MHC class I- tumours of HPV16 origin. Enhancement of DNA vaccine potency via MHC- and/or receptor- mediated targeting signals. Enhancement of DNA vaccine potency by linkage of mouse heat shock protein 70.1 gene to the HPV16 E7 gene. Enhancement of DNA vaccine potency via MHC- and/or receptor- mediated targeting signals. Enhancement of DNA vaccine potency via MHC- and/or receptor-mediated targeting signals. Oncogenicity and immunogenicity of gene-modiefied HPV16-transformed cells. Anticancer vaccines and gene therapy. Vaccination with HPV16-transformed cells expressing suicide gene and IL-2 or GM-CSF in a MHC-I negative cervical carcinoma mouse model. Therapy of HPV16-induced carcinoma with IL2 gene modified and dendritic cell (DC)-based tumour vaccines. DNA vaccine against Friend erythroleukaemia virus. DNA vaccines. The effect of immunomodulatory genes in enhancement of HPV DNA vaccine potency against oncogenic cells with different level of MHC class I expression. The effect of immunomodulatory genes in enhancement of HPV DNA vaccine potency against oncogenic cells with different level of MHC class I expression. Zlepšení imunizačního účinku DNA vakcíny pro terapii cervikálního karcinomu. Chemoimmunotherapy of cancer: potentiated effectiveness of granulocyte-macrophage colony-stimulating factor and ifosfamide derivative CBM-4A. Local IFN-gama therapy of HPV16-associated tumours. Local IFN-gamma therapy of HPV16-associated tumours. DNA vaccines and their use for immunization against tumors induced by human papillomaviruses. Modified HPV16 E7 Genes as DNA Vaccine against E7-Containing Oncogenic Cells. Mouse model of human papillomavirus-associated tumors with downregulated MHC class I expression. Metastatic MHC class I-negative mouse cells derived by transformation with human papillomavirus type 16. Immunisation with modified HPV16 E7 genes against mouse oncogenic TC-1 cell sublines with downregulated expression of MHC class I molecules. Immunization with live HPV-16-transformed mouse cells expressing the herpes simplex thymidine kinase and either GM-CSF or IL-2. Immunization with transduced tumor cells expressing suicide gene and GM-CSF or IL-2.
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/NC5900/2000/ico%3A00023736 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/NC5900/2001/ico%3A00023736 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/NC5900/2002/ico%3A00023736 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/NC5900/2003/ico%3A00023736

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