About: Metastatic MHC class I-negative mouse cells derived by transformation with human papillomavirus type 16.

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About: Metastatic MHC class I-negative mouse cells derived by transformation with human papillomavirus type 16. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Mouse cells were transformed with E6/E7 HPV 16 and activatedH-ras oncogenes. An oncogenic cell line, designatedMK16/1/IIIABC, was derived, lacking MHC class I and II molecules on the cell surface and forming metastases in lymph nodes and lungs after prolonged growth of s.c. induced limited protection against challenge with homologous cells. These cells can therefore serve as a model for studying immune reactions against HPV 16-associated tumours. Mouse cells were transformed with E6/E7 HPV 16 and activatedH-ras oncogenes. An oncogenic cell line, designatedMK16/1/IIIABC, was derived, lacking MHC class I and II molecules on the cell surface and forming metastases in lymph nodes and lungs after prolonged growth of s.c. induced limited protection against challenge with homologous cells. These cells can therefore serve as a model for studying immune reactions against HPV 16-associated tumours. (en)
Title	Metastatic MHC class I-negative mouse cells derived by transformation with human papillomavirus type 16. Metastatic MHC class I-negative mouse cells derived by transformation with human papillomavirus type 16. (en)
skos:prefLabel	Metastatic MHC class I-negative mouse cells derived by transformation with human papillomavirus type 16. Metastatic MHC class I-negative mouse cells derived by transformation with human papillomavirus type 16. (en)
skos:notation	RIV/68378050:_____/01:23010265!RIV/2003/AV0/A23003/N
http://linked.open.../vavai/riv/strany	374;380
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA102/97/0542), P(GA312/98/0826), P(GA312/99/0542), P(NC45011), P(NC5526), P(NC5900), Z(AV0Z5052915), Z(MZ00020980501)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Mikyšková, Romana Šímová, Jana Bubeník, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	686601
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/01:23010265
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	human papillomavirus; - E6/E7 oncogenes; - cell transformation (en)
http://linked.open.../riv/klicoveSlovo	human papillomavirus - E6/E7 oncogenes - cell transformation
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[0965CD18EA3A]
http://linked.open...i/riv/nazevZdroje	British Journal of Cancer
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of software tools for partable and safety applications in industrial process control Development of new vaccines or gene therapy of cancer, based on cooperation of APC and TH cells Experimental gene therapy of virus-induced tumours Gene Therapy of Cancer - Optimization of Therapeutic Protocols Combined therapy of minimal residual disease using IL-2 and GM-CSF as recombinant cytokines or genetically modified vaccines Gene immunotherapy of tumours with different expression of MHC-I.
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	84
http://linked.open...iv/tvurceVysledku	Povýšil, C. Bubeník, Jan Mikyšková, Romana Šímová, Jana Jelínek, F. Kovařík, J. Ludvíková, V. Šmahel, M. Sobotková, E. Vonka, V. Žák, R. Marinov, J.
http://linked.open...n/vavai/riv/zamer	Biologické, genetické a epidemiologické aspekty malignit a optimalizace diagnosticko-léčebných postupů Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	0007-0920
number of pages	6 (xsd:int)

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