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| Description
| - Cascade reactions represent the current trend in biocatalysis as means to improve its economic and ecological viability (due to no need for intermediate isolation, better product purity, racemization of substrates or regeneration of cofactor in situ). The project aim is to examine the possibilities of multistep catalysis in nitrile biotransformations leading to high-value carboxylic acids (nicotinic, isonicotinic, mandelic, lysergic etc.) and hydroxamic acids (chelators). The action of nitrilases and amidases will be integrated to produce high-purity carboxylic acids from nitriles (the role of amidase being hydrolysis of the nitrilase by-products, amides). Nitrile hydratases (or mild chemical catalysts) and amidases from different strains will be combined to give carboxylic acids from nitriles, if enzymes produced by single strain are not compatible in terms of substrate specificity. The same enzymes will be used to afford hydroxamic acids by carrying out the amidase-catalyzed reaction in presence of (en)
- Kombinací (bio)katalytických kroků provést v laboratorních podmínkách transformace nitrilů vedoucí ke sloučeninám průmyslového významu nebo využitelné pro screening enzymů.
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| Title
| - Cascade chemoenzymatic reactions of nitriles (en)
- Kaskádové chemoenzymatické reakce nitrilů
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - biocatalysis; biotransformation; cascade reactions; nitriles; amides; carboxylic acids; hydroxamic acids; nitrilase; nitrile hydratase; amidase (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - Kaskádové reakce katalyzované chemicky a enzymy (nitrilhydratasami, amidasami, nitrilasami, lipasami) byly použity k přípravě farmaceutických produktů v laboratorním měřítku (cyklofelitolů - inhibitorů glukosidas, hydroxamátů - chelatačních činidel), intermediátů přírodních látek nebo semisyntetických antibiotik aj. Princip kaskádových reakcí byl využit také ke stanovení těchto enzymů. (cs)
- Cascade reactions catalyzed chemically and by enzymes (nitrile hydratases, amidases, nitrilases, lipases) were applied to prepare pharmaceutical products on laboratory scale (cyclophellitols - glucosidase inhibitors, hydroxamates - chelating agents), intermediates of natural compounds or semisynthetic antibiotics etc. The principle of cascade reactions was also used for enzyme assays. (en)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - biocatalysis
- biotransformation
- nitrilase
- nitrile hydratase
- amides
- carboxylic acids
- cascade reactions
- hydroxamic acids
- nitriles
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| is http://linked.open...vavai/riv/projekt
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| is http://linked.open...vavai/cep/projekt
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