About: Biotransformation of benzonitrile herbicides via the nitrile hydratase-amidase pathway in rhodococci

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About: Biotransformation of benzonitrile herbicides via the nitrile hydratase-amidase pathway in rhodococci Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1007/s10295-012-1184-z
Description	The aim of this work was to determine the ability of rhodococci to transform 3,5-dichloro-4-hydroxybenzonitrile (chloroxynil), 3,5-dibromo-4-hydroxybenzonitrile (bromoxynil), 3,5-diiodo-4-hydroxybenzonitrile (ioxynil) and 2,6-dichlorobenzonitrile (dichlobenil); to identify the products and determine their acute toxicities. Rhodococcus erythropolis A4 and Rhodococcus rhodochrous PA-34 converted benzonitrile herbicides into amides, but only the former strain was able to hydrolyze 2,6-dichlorobenzamide into 2,6-dichlorobenzoic acid, and produced also more of the carboxylic acids from the other herbicides compared to strain PA-34. Transformation of nitriles into amides decreased acute toxicities for chloroxynil and dichlobenil, but increased them for bromoxynil and ioxynil. The amides inhibited root growth in Lactuca sativa less than the nitriles but more than the acids. The conversion of the nitrile group may be the first step in the mineralization of benzonitrile herbicides but cannot be itself considered to be a detoxification. The aim of this work was to determine the ability of rhodococci to transform 3,5-dichloro-4-hydroxybenzonitrile (chloroxynil), 3,5-dibromo-4-hydroxybenzonitrile (bromoxynil), 3,5-diiodo-4-hydroxybenzonitrile (ioxynil) and 2,6-dichlorobenzonitrile (dichlobenil); to identify the products and determine their acute toxicities. Rhodococcus erythropolis A4 and Rhodococcus rhodochrous PA-34 converted benzonitrile herbicides into amides, but only the former strain was able to hydrolyze 2,6-dichlorobenzamide into 2,6-dichlorobenzoic acid, and produced also more of the carboxylic acids from the other herbicides compared to strain PA-34. Transformation of nitriles into amides decreased acute toxicities for chloroxynil and dichlobenil, but increased them for bromoxynil and ioxynil. The amides inhibited root growth in Lactuca sativa less than the nitriles but more than the acids. The conversion of the nitrile group may be the first step in the mineralization of benzonitrile herbicides but cannot be itself considered to be a detoxification. (en)
Title	Biotransformation of benzonitrile herbicides via the nitrile hydratase-amidase pathway in rhodococci Biotransformation of benzonitrile herbicides via the nitrile hydratase-amidase pathway in rhodococci (en)
skos:prefLabel	Biotransformation of benzonitrile herbicides via the nitrile hydratase-amidase pathway in rhodococci Biotransformation of benzonitrile herbicides via the nitrile hydratase-amidase pathway in rhodococci (en)
skos:notation	RIV/00216208:11310/12:10125772!RIV13-GA0-11310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GAP504/11/0394), P(GD305/09/H008), P(OC09046), S
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Šulc, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	125200
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/12:10125772
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Rhodococcus rhodochrous; Rhodococcus erythropolis; benzonitrile herbicides; amidase; nitrile hydratase (en)
http://linked.open.../riv/klicoveSlovo	amidase benzonitrile herbicides nitrile hydratase Rhodococcus rhodochrous Rhodococcus erythropolis
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[BA328B05AEFF]
http://linked.open...i/riv/nazevZdroje	Journal of Industrial Microbiology and Biotechnology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Interspecies comparison of nitrilases by using recombinant enzymes obtained by database-mining: their environmental impact and potential application Preparation, biotransformation, and optimalization of compounds with antitumor and antimicrobial effects Cascade chemoenzymatic reactions of nitriles
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	39
http://linked.open...iv/tvurceVysledku	Lovecká, Petra Macková, Martina Martínková, Ludmila Pelantová, Helena Šulc, Miroslav Pátek, Miroslav Bhalla, Tek Chand Pasquarelli, Fabrizia Pičmanová, Martina Thimová, Markéta Veselá, Alicja Barbara
http://linked.open...ain/vavai/riv/wos	000311205800009
issn	1367-5435
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s10295-012-1184-z
http://localhost/t...ganizacniJednotka	11310
is http://linked.open...avai/riv/vysledek of	Biotransformation of benzonitrile herbicides via the nitrile hydratase-amidase pathway in rhodococci

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